Clinical and pathophysiological understanding of the hepatorenal syndrome: Still wrong or still not exactly right?

Figure 1 Pathophysiology of hepatorenal syndrome. The interplay between infection, inflammation, hypometabolism, loss of function and hepatorenal syndrome is depicted. HRS: Hepatorenal syndrome; IL-6: Interleukin 6; BTN: Bacterial translocation; PAMP: Pathogen associated molecular patterns; TLR4: Toll-like receptor 4; LPS: Lipopolysaccharide.