Metformin effect on internal carotid artery blood flow assessed by area under the curve of carotid artery Doppler in women with polycystic ovarian syndrome

Table 2 Correlations of area under the curve - internal carotid artery Doppler vs study variables over 6 mo with metformin therapy for women recruited to this study

AUC- ICA vs parameter	Coefficient of correlation	P value
Cholesterol in mg/dL	0.81	0.03
HDL in mg/dL	-0.92	0.002
LDL in mg/dL	0.88	0.04
HOMA_IR	0.98	0.0001
SHBG in nmole/L	-0.90	0.01
Testosterone in ng/dL	0.86	0.001
LH/ FSH_ratio	0.91	0.007
PI	0.87	0.002
RI	0.8	0.009
CIMT in mm	0.95	0.0001
24 wk of metformin therapy	-0.99	0.001

Data are presented as means ± standard deviation. HDL: High-density lipoprotein; LDL: Low-density lipoprotein; SHBG: Low hormone binding globulin; FSH: Follicular stimulating hormone; LH: Luteinizing hormone; HOMA-IR: Homeostasis model assessment for insulin resistance; PI: Homeostasis index; RI: Resistance index; CIMT: Carotid artery intima-media thickness.