Early postsurgical lethal outcome due to splenic littoral cell angioma: A case report

Figure 3 Pathological examination. A: The lesion was located in the splenic red pulp, nearly all the surrounding tissues were invaded by the tumor cells (H&E magnification × 20); B: The lesion consists of a large amount of variably sized sinuses with anastomosing vascular channels lined by relatively plump round to columnar histiocytic-endothelial littoral cells, some cells with small nucleus with deep chromatin, some columnar cells with large nucleus with vacuolated chromatin, some exfoliated into the expanded sinuses (H&E magnification × 400); C-F: Immunohistochemical staining confirming endothelial differentiation with CD31, CD34, ERG, and FVIII (magnification × 200); G and H: Immunohistochemical staining confirming histiocytic differentiation with CD68 and CD21 (magnification × 200); I: Ki-67 labeling index was no more than 20% (magnification × 200).