Novel gene mutation in maturity-onset diabetes of the young: A case report

Figure 1 Partial sequence diagram of KLF11 and the pedigree of the studied family members. A: The pedigree of the study family. Women are represented using circles, and men are represented using squares. The black symbols indicate individuals with diabetes. The shadow symbol indicates individuals with prediabetes. The patient is denoted by an arrow. N/M or N/N indicates individuals who underwent molecular analyses. The p. D11N variant of KLF11 was identified in the patient, mother, grandmother, and young aunt. The N symbols denote the people who carry the normal gene, and the M symbols denote the people who carry the D11N variant; B: Partial sequence diagram of KLF11. A heterozygous c. G31A transition mutation causing the substitution of aspartic acid by asparagine at codon 11 is shown by an arrow (GenBank accession number: NM_003597).