Improvement of inflammatory response and gastrointestinal function in perioperative of cholelithiasis by Modified Xiao-Cheng-Qi decoction

Table 8 Levels of the indicators for acute inflammatory stress response and substance P in the perioperative period of biliary tract surgery

Indicators	Control (n = 53)	XD (n = 54)	MXD (n = 55)	P value
IL-6 (pg/mL)
1 d before surgery	4.89 ± 1.24	4.43 ± 1.46	4.26 ± 2.62	0.203
1 d after surgery	17.42 ± 6.671	10.63 ± 9.991,2	9.08 ± 8.631,2	0.000
2 d after surgery	11.09 ± 3.571	9.80 ± 6.511	6.13 ± 3.601,2,3	0.000
5 d after surgery	8.49 ± 2.311	7.22 ± 2.171	7.22 ± 3.391	0.487
IL-10 (pg/mL)
1 d before surgery	1.29 ± 0.50	1.25 ± 0.46	1.24 ± 0.23	0.798
1 d after surgery	1.27 ± 0.49	1.20 ± 0.61	1.21 ± 0.50	0.761
2 d after surgery	1.21 ± 0.51	1.23 ± 0.50	1.19 ± 0.37	0.942
5 d after surgery	1.33 ± 0.55	1.45 ± 0.53	1.39 ± 0.42	0.865
CRP (ng/mL)
1 d before surgery	6.19 ± 1.77	5.69 ± 2.40	5.59 ± 1.87	0.273
1 d after surgery	16.85 ± 7.731	10.84 ± 8.381,2	8.02 ± 3.441,2,3	0.000
2 d after surgery	17.90 ± 17.361	14.41 ± 11.361	8.83 ± 2.841,2,3	0.001
5 d after surgery	10.33 ± 3.111	10.49 ± 1.45	8.52 ± 2.68	0.170
SAA (ng/mL)
1 d before surgery	426.21 ± 48.96	415.64 ± 40.60	411.00 ± 47.39	0.214
1 d after surgery	9492.64 ± 1738.161	7807.52 ± 936.931,2	6953.98 ± 1228.381,2,3	0.000
2 d after surgery	14792.13 ± 6501.471	10573.74 ± 4074.711,2	9341.03 ± 1888.411,2	0.000
5 d after surgery	7817.09 ± 550.521	7396.66 ± 611.021	6911.41 ± 1464.141	0.132
Substance P (pg/mL)
1 d before surgery	40.73 ± 21.53	35.61 ± 19.79	36.14 ± 31.12	0.501
1 d after surgery	33.60 ± 16.051	37.30 ± 16.07	49.25 ± 41.491,2,3	0.009
2 d after surgery	28.23 ± 11.121	45.58 ± 24.071,2	51.73 ± 26.871,2	0.000
5 d after surgery	28.29 ± 11.90	27.55 ± 23.99	35.48 ± 23.70	0.653

¹P < 0.05 vs the same group before surgery.

²P < 0.05 vs the control group.

³P < 0.05 vs Xiao-Cheng-Qi decoction.

XD: Xiao-Cheng-Qi decoction; MXD: Modified Xiao-Cheng-Qi decoction; IL: Interleukin; CRP: C-reactive protein; SAA: Serum amyloid A.