Iris metastasis from clear cell renal cell carcinoma: A case report

Table 1 Metastasis to the iris from renal cell carcinoma: Summarized data

Ref.	Sex	Age in year	Presenting symptoms	Tumor size	Type of RCC	Time to detection of iris metastasis after diagnosis of primary RCC	Simultaneous lung metastasis	Other metastatic sites	Systemic outcome
Lopes Abath Neto et al[2]	Male	56	Painless blurred vision in right eye	3.5 mm × 2.2 mm	ccRCC (right)	Iris metastasis is the first manifestation	NA	Nothing	Alive
Ware et al[3]	Male	70	Iris mass in left eye	3 mm × 2 mm	RCC (left)	Iris metastasis is the first manifestation	NA	Conjunctiva	NA
Shome et al[4]	Male	67	Progressive painless vision loss in left eye for 3 mo	2.8 mm × 1.5 mm	ccRCC (right)	14 mo	Yes	Bone, lymph node	Alive
Ikeda et al[7]	Male	55	Decreased vision in the right eye	8 mm × 4 mm	ccRCC (right)	21 mo	Yes	Brain, liver, bone, lymph nodes	Deceased
Marie-Louise et al[12]	Male	NA	Ocular tumor, ocular hypertension	NA	ccRCC	NA	NA	Cerebellar	Alive
Wyzinski et al[13]	Male	60	Sudden and painless loss of vision in right eye (bilateral mass)	2.8 mm	RCC (left)	Iris metastasis is the first manifestation	NA	Nothing	Deceased
Mello et al[14]	Male	61	Blurred vision and iris lesion in right eye	7 mm × 4 mm	Renal adenocarcinoma	5 yr	Yes	Cerebrum, liver	Alive
Ramskold et al[15]	Male	63	Pain in right eye, photophobia	8.1 mm × 5.7 mm × 4.6 mm	RCC (left)	2 yr	Yes	Mediastinum, paratracheal lymph nodes	NA
Lou and Zhang[16]	Male	54	Foreign body sensation in left eye	Mung bean size	ccRCC (left)	1 mo	Yes	Nothing	NA
Xing[17]	Male	59	Blurred vision in left eye; pain and exophthalmia in right eye	4 mm × 4 mm	ccRCC (right)	2 mo	NA	Brain, skin, rib	Deceased
Lu et al[18]	Male	59	Left eye secretions, foreign body sensation, red eye, swelling pain, vision loss, ipsilomatous headache, nausea, vomiting	4.5 mm × 3 mm × 1.5 mm	ccRCC (right)	Iris metastasis is the first manifestation	NA	Nothing	Deceased
This study	Male	62	Blurred vision, red eyes, mass on iris in right eye	10 mm	ccRCC (left)	13 yr	NA	Nothing	Alive

Data in the table are based on the availability of data in the original articles. ccRCC: Clear cell renal cell carcinoma; NA: Details of case not available; RCC: Renal cell carcinoma.