Efficacy of prednisone combined with mycophenolate mofetil for immunoglobulin A nephropathy with moderate-to-severe renal dysfunction

Table 2 Renal function and proteinuria before and after treatment in both groups

Project	Time	GTG	ITG	t value	P value
24-h urinary protein quantification (g)	Before the treatment	4.01 ± 1.43	3.86 ± 1.37	0.597	0.551
	3 mo after treatment	2.57 ± 0.69a	2.40 ± 0.91a	1.192	0.236
	6 mo after treatment	1.62 ± 0.67a	1.54 ± 0.75a	0.632	0.529
	9 mo after treatment	1.09 ± 0.61a	0.89 ± 0.50a	1.985	0.049
	12 mo after treatment	0.68 ± 0.38a	0.39 ± 0.42a	4.062	< 0.001
Scr (μmol/L)	Before the treatment	121.51 ± 14.58	122.16 ± 15.29	0.244	0.808
	3 mo after treatment	113.02 ± 21.63a	112.00 ± 24.72a	0.247	0.805
	6 mo after treatment	108.15 ± 35.2 a	105.99 ± 34.22a	0.34	0.72
	9 mo after treatment	96.81 ± 34.60 a	82.23 ± 31.41a	2.454	0.016
	12 mo after treatment	80.30 ± 7.45 a	64.76 ± 18.32 a	11.053	< 0.001

^aP < 0.05, compared to before treatment.

GTG: Glucocorticoid therapy group; ITG: Immunosuppressive therapy group; Scr: Serum creatinine.