Hemophagocytic lymphohistiocytosis with jaundice as first manifestation: A case report

Table 2 Diagnostic guidelines for hemophagocytic lymphohistiocytosis in 2004

Diagnostic criteria
1	Molecular diagnosis consistent with HLH
2	Five of the following eight criteria are fulfilled
	Fever
	Splenomegaly
	Cytopenias affecting at least two of the three lineages in the peripheral blood; hemoglobin < 90 g/L; platelets < 100 × 109; neutrophils < 1 × 109
	Hypertriglyceridemia and/or hypofibrinogenemia
	Hemophagocytosis in bone marrow, spleen, or lymph nodes
	Low or absent natural killer cell activity
	Hyperferritinemia
	Soluble interleukin-2 receptor alpha subunit ≥ 2400 U/mL