Prenatal ultrasound diagnosis of congenital infantile fibrosarcoma and congenital hemangioma: Three case reports

Table 2 Literature review of cases with both ultrasound findings and NTRK3 gene diagnosis of congenital infantile fibrosarcoma

Ref.	GA at diagnosis (wk)	Sex	Site	Size (cm)	Coagulopathy	Treatment	Outcome	GA at delivery (wk)	Modality of delivery	Birth weight (kg)	Prenatal ultrasound findings	Immunochemistry	ETV6/NTRK3 gene fusion detected	Affected organs or metastasis
Nonaka et al[7], 2004	19	Male	Back	6.1×2.2	-	-	-	29	Pregnancy terminated at 29 wk	1.4	Solid mass involving the soft tissue at the rightparaspinal area	Vim(+)	Yes	Liver and left adrenal gland
Al-Salem et al[4], 2011	-	Male	Sacrococcygeal	12.0×10.0	-	S	No recurrence during follow-up	40	Cesarean section	4.1	Not described in detail	Vim(+), Ki67(+)> 5%	Yes	Bone margin and skeletal muscle
Dumont et al[8], 2011	36	Male	Right leg	9.0×8.0	Hemorrhagic shock	S*	Died at day 8 of life	38	Cesarean section	3.3	Poorly vascularized	Vim(+)	Yes	-
Tsang et al[9], 2013	37	-	Right frontal	9.0×7.0	-	S	No recurrence during follow-up	37	Cesarean section	-	Not described in detail	Vim(+)	Yes	Skull
Kraneburg et al[10], 2013	36	Male	Left leg	11.8×9.3	Bleeding, anemia, hypovolemia	S*	No recurrence during follow-up	36	Vaginal delivery	2.1	Well-circumscribed, intracavitary, homogenous solid mass	-	Yes	-
Sıvrıkoz et al[11], 2020	24	Male	Anterior fetal neck and oropharyngeal	5.5×5.4	-	S+C	No recurrence during follow-up	36	Cesarean section	2.9	Hypervascular with irregular borders	Ki-67(+) 1%	Yes	Masseter muscle, parotid gland, thyroid gland
The present study, 2022	28	Male	Left axilla to the left chest wall	3.2×3.0	Consumptive coagulation dysfunction	S+C	No recurrence during follow-up	37	Cesarean section	2.6	Well-defined, heterogeneous with abundant blood flow	Ki-67 (+) 20%, SMA (+), CD34 (+) and CD31 (+)	Yes	Pectoralis and adjacent ribs

GA: Gestational age; S: Surgery; C: Chemotherapy; *: Amputation; vim: Vimentin; -: Not mentioned; SMA: Smooth muscle actin.