Evidence-Based Medicine
Copyright ©The Author(s) 2023.
World J Clin Cases. Oct 26, 2023; 11(30): 7318-7328
Published online Oct 26, 2023. doi: 10.12998/wjcc.v11.i30.7318
Table 2 Mendelian randomization for the association of cheese intake with gestational hypertension and gestational diabetes
OutcomesTraitNumber of instrumentsMethodOR95%CIP valueHeterogeneity
Pleiotropy
Q statistic
P value
Intercept
P value
Gestational hypertensionPregnancy hypertension62MR Egger0.400.09-1.750.22973.040.1200.0060.634
62Weighted median0.550.34-0.900.017
62Inverse variance weighted0.570.40-0.801.377e-373.310.134
62Weighted mode0.490.20-1.190.121
Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium62MR Egger0.620.15-2.520.50576.440.0754.3e-40.971
62Weighted median0.690.45-1.050.083
62Inverse variance weighted0.630.46-0.880.00676.440.088
62Weighted mode0.690.28-1.680.416
Gestational diabetesGestational diabetes (for exclusion)62MR Egger0.230.04-1.380.11383.730.0239.5 e-30.537
62Weighted median0.400.23-0.711.507e-3
62Inverse variance weighted0.390.26-0.601.822e-584.260.025
62Weighted mode0.320.10-1.030.062
Diabetes mellitus in pregnancy62MR Egger0.460.07-3.000.41891.395.586e-3-0.0010.948
62Weighted median0.350.20-0.622.998e-4
62Inverse variance weighted0.430.28-0.671.718 e-491.47.089e-3
62Weighted mode0.210.04-1.200.085