Clinical implications of forkhead box M1, cyclooxygenase-2, and glucose-regulated protein 78 in breast invasive ductal carcinoma

Table 4 Univariate analysis of prognostic mortality in breast infiltrating ductal carcinoma

	Surviving patients (n = 53)	Dead patients (n = 12)	t/χ2	P value
Age (yr)			9.849	0.002b
≤ 60	31 (58.49)	1 (8.33)
> 60	22 (41.51)	11 (91.67)
Family disease history of BC			0.562	0.453
Yes	9 (16.98)	1 (8.33)
No	44 (83.02)	11 (91.67)
Long-term smoking			0.686	0.408
Yes	15 (28.30)	12 (16.67)
No	38 (71.70)	10 (83.33)
Long-term drinking			0.102	0.749
Yes	11 (20.75)	12 (16.67)
No	42 (79.25)	10 (83.33)
History of breast disease			1.646	0.200
Yes	19 (35.85)	12 (16.67)
No	34 (64.15)	10 (83.33)
Histological grade			37.350	< 0.001b
Grade I	35 (66.04)	0 (0.0)
Grade II	16 (30.19)	3 (25.00)
Grade III	2 (3.77)	9 (75.00)
Tumor metastasis			30.840	< 0.001b
Yes	9 (16.98)	12 (100.0)
No	44 (83.02)	0 (0.0)
FOXM1	4.49 ± 0.69	5.22 ± 0.80	3.214	0.002b
COX-2	3.28 ± 0.70	3.96 ± 0.84	2.928	0.005b
GRP78	2.83 ± 0.62	3.66 ± 0.66	4.140	< 0.001b

^bP <0.01 vs surviving patients.

FOXM1: Forkhead box M1; COX-2: Cyclooxygenase-2; GRP78: Glucose-regulated protein 78; BC: Breast cancer.