Clinical implications of forkhead box M1, cyclooxygenase-2, and glucose-regulated protein 78 in breast invasive ductal carcinoma

Table 3 Correlation of forkhead box M1, cyclooxygenase-2, and glucose-regulated protein 78 with clinicopathological features of breast infiltrating ductal carcinoma

	n	FOXM1	COX-2	GRP78
Age (yr)
≤ 60	33	4.51 ± 0.69	3.22 ± 0.61	3.85 ± 0.71
> 60	32	4.75 ± 0.83	3.60 ± 0.87	3.12 ± 0.69
Family history of BC
Yes	10	4.66 ± 0.61	3.42 ± 0.65	3.05 ± 0.64
No	55	4.43 ± 1.37	3.31 ± 1.28	2.62 ± 0.95
Long-term smoking
Yes	17	4.65 ± 0.49	3.59 ± 0.54	2.96 ± 0.49
No	48	4.62 ± 0.84	3.34 ± 0.83	2.99 ± 0.77
Long-term drinking
Yes	13	4.36 ± 0.80	3.36 ± 0.91	2.81 ± 0.58
No	52	4.69 ± 0.75	3.41 ± 0.74	3.03 ± 0.73
History of breast disease
Yes	21	4.49 ± 0.63	3.42 ± 0.61	2.77 ± 0.59
No	44	4.69 ± 0.82	3.40 ± 0.84	3.08 ± 0.74
Histological grade
Grade I	35	4.39 ± 0.76	3.21 ± 0.72	2.75 ± 0.66
Grade II	19	4.57 ± 0.47	3.29 ± 0.61	2.91 ± 0.49
Grade III	11	5.48 ± 0.611,2	4.22 ± 0.701,2	3.83 ± 0.521,2
Tumor metastasis
Yes	21	5.03 ± 0.75	3.7 ± 0.78	3.41 ± 0.69
No	44	4.43 ± 0.703	3.24 ± 0.713	2.78 ± 0.623

¹Indicates a statistically significant difference from grade I patients.

²Indicates a statistically significant difference from grade II patients.

³Indicates a statistically significant difference from metastatic patients.

FOXM1: Forkhead box M1; COX-2: Cyclooxygenase-2; GRP78: Glucose-regulated protein 78; BC: Breast cancer.