Usefulness of analyzing endoscopic features in identifying the colorectal serrated sessile lesions with and without dysplasia

Figure 2 Histopathological demonstration of colorectal the sessile serrated lesion and sessile serrated lesion-dysplasia (hematoxylin and eosin, objective magnifications 20 ×, 3DHISTECH). A: The crypt has at least one of the following histologic features: (1) Horizontal growth along the mucosal muscle layer (L or inverted T-shaped crypt structure); (2) Expansion of the crypt base (basal 1/3 of the crypt base); (3) Jagged swelling of the crypt base; and (4) Asymmetric hyperplasia (proliferative band extending laterally from the base); B: Complex structural abnormalities, including: (1) Crypt elongation, crowding, complex branching, sieve-like structures, and villi-like structures; and (2) Cytologic abnormalities of diverse morphology, either with cuboidal cells, eosinophilic cytoplasm, vesicular nuclei, and prominent nucleoli, or with elongated cells, eosinophilic cytoplasm, deep-stained nuclei, and pseudostratified nuclei, with common nuclear schizophrenic signs.