Acute cholangitis: Does malignant biliary obstruction vs choledocholithiasis etiology change the clinical presentation and outcomes?

doi:10.12998/wjcc.v11.i29.6984

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Oct 16, 2023 (publication date) through Jun 19, 2024

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World Journal of Clinical Cases

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Retrospective Cohort Study

World J Clin Cases. Oct 16, 2023; 11(29): 6984-6994
Published online Oct 16, 2023. doi: 10.12998/wjcc.v11.i29.6984

Table 4 Univariate and multivariate analyses of factors associated with 30-d mortality

Variables		Univariate analysis		Multivariate analysis
Variables		OR (95%CI)	P value	OR (95%CI)	P value
Age	Every 1-yr increase	1.015 (0.964-1.068)	0.576	-	-
Sex	Male	0.143 (0.017-1.237)	0.077	-	-
Sex	Female	Referent	0.077	-	-
Etiology	MBO	8.623 (1.697-43.806)	0.009	5.346 (0.524-54.491)	0.157
Etiology	CBDS	Referent	0.009	5.346 (0.524-54.491)	0.157
Fever (BT ≥ 39 °C)	Yes	1.394 (0.160-12.121)	0.764	-	-
Fever (BT ≥ 39 °C)	No	Referent	0.764	-	-
Abnormal WBC count	Yes	1.411 (0.256-7.776)	0.692	-	-
Abnormal WBC count	No	Referent	0.692	-	-
Hyperbilirubinemia (≥ 5 mg/dL)	Yes	0.836 (0.152-4.608)	0.837	-	-
Hyperbilirubinemia (≥ 5 mg/dL)	No	Referent	0.837	-	-
Time to ERCP	Every 1-d delay	1.931 (1.210-3.081)	0.006	1.977 (1.027-3.807)	0.041
Failure of ERCP	Yes	16.88 (1.696-166.389)	0.016	27.116 (0.979-751.028)	0.051
Failure of ERCP	No	Referent	0.016	27.116 (0.979-751.028)	0.051
Hepatic dysfunction (PT-INR > 1.5)	Yes	17.917 (2.986–107.492)	0.002	NI	-
Hepatic dysfunction (PT-INR > 1.5)	No	Referent	0.002	NI	-
Hematological dysfunction (PLT < 100 × 10³/µL)	Yes	3.058 (0.347-26.987)	0.314	-	-
Hematological dysfunction (PLT < 100 × 10³/µL)	No	Referent	0.314	-	-
Renal dysfunction (Cr > 2.0 mg/dL)	Yes	2.315 (0.264-20.300)	0.449	-	-
Renal dysfunction (Cr > 2.0 mg/dL)	No	Referent	0.449	-	-
Respiratory dysfunction (PaO₂/FiO₂ ratio > 300)	Yes	14.455 (2.807-74.421)	0.001	NI	-
Respiratory dysfunction (PaO₂/FiO₂ ratio > 300)	No	Referent	0.001	NI	-
Neurological dysfunction (conscious disturbance)	Yes	17.889 (3.447-92.828)	0.001	NI	-
Neurological dysfunction (conscious disturbance)	No	Referent	0.001	NI	-
Cardiovascular dysfunction¹	Yes	29.600 (5.450–154.322)	< 0.001	NI	-
Cardiovascular dysfunction¹	No	Referent	< 0.001	NI	-
Multiple organ dysfunction (≥ 2 organ dysfunction)	Yes	33.172 (5.833-188.666)	< 0.001	49.008 (1.692-1419.861)	0.023
Multiple organ dysfunction (≥ 2 organ dysfunction)	No	Referent	< 0.001	49.008 (1.692-1419.861)	0.023
Severity of AC	Severe	17.174 (1.986-148.479)	0.01	1.496 (0.053-41.837)	0.813
Severity of AC	Moderate + mild	Referent	0.01	1.496 (0.053-41.837)	0.813
ICU admission	Yes	8.944 (1.568-51.014)	0.014	13.667 (0.993-188.394)	0.051
ICU admission	No	Referent	0.014	13.667 (0.993-188.394)	0.051

¹Defined as hypotension requiring dopamine ≥ 5 µg/kg per min, or any dose of norepinephrine.

MBO: Malignant biliary obstruction; CBDS: Common bile duct stones; NI: Not included; AC: Acute cholangitis; BT: Body temperature; WBC: White blood cell count; ERCP: Endoscopic retrograde cholangiopancreatography; Cr: creatine; PT/INR: Prothrombin time/international normalized ratio; PLT: platelet; ICU: Intensive care unit; OR: Odds ratios; CI: Confidence intervals.

Citation: Tsou YK, Su YT, Lin CH, Liu NJ. Acute cholangitis: Does malignant biliary obstruction vs choledocholithiasis etiology change the clinical presentation and outcomes? World J Clin Cases 2023; 11(29): 6984-6994
URL: https://www.wjgnet.com/2307-8960/full/v11/i29/6984.htm
DOI: https://dx.doi.org/10.12998/wjcc.v11.i29.6984