Effects of different doses of long-acting growth hormone in treating children with growth hormone deficiency

Table 3 Comparison of insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in high-dose and low-dose groups (mean ± SD)

Group	IGF-1				IGFBP-3
	Before	After	t value	P value	Before	After	t value	P value
HDG (n = 23)	127.15 ± 63.39	259.17 ± 124.86	4.522	0.000	4.18 ± 0.86	5.64 ± 1.41	4.237	0.000
LDG (n = 21)	115.39 ± 62.65	253.11 ± 149.52	3.893	0.000	3.57 ± 0.72	5.37 ± 1.11	6.269	0.000
t value	0.618	0.146			2.547	0.691
P value	0.540	0.884			0.015	0.493

HDG: High-dose group; LDG: Low-dose group; IGF-1: Insulin-like growth factor-1; IGFBP-3: Insulin-like growth factor-binding protein-3.