Clinical value of chemiluminescence method for detection of antinuclear antibody profiles

Table 4 Diagnostic performance of antibodies detected by chemiluminescence assay and line immunoassay for systemic lupus erythematosus

Antibodies	Chemiluminescence method		Line immunoassay
	AUC	95%CI	AUC	95%CI
Anti-double-stranded DNA (dsDNA) antibody	0.935	0.907-0.962	0.905	0.871-0.940
Anti-histone (Histone) antibody	0.508	0.436-0.580	0.513	0.441-0.585
Anti-nucleosome (Nuc) antibody	0.837	0.788-0.886	0.829	0.780-0.879
Anti-Smith (Sm) antibody	0.941	0.914-0.968	0.907	0.872-0.943
Anti-ribosomal P protein (Rib-P) antibody	0.776	0.721-0.831	0.791	0.738-0.844
Anti-sicca syndrome A (Ro60) antibody	0.953	0.931-0.975	0.945	0.921-0.969
Anti-sicca syndrome A (Ro52) antibody	0.946	0.920-0.972	0.929	0.900-0.958
Anti- sicca syndrome (SSB) antibody	0.650	0.584-0.716	0.661	0.596-0.727
Anti-centromere protein B (Cenp-B) antibody	0.811	0.761-0.861	0.787	0.733-0.841
Anti-DNA topoisomerase 1 (Scl-70) antibody	0.783	0.727-0.838	0.740	0.681-0.800
Anti-histidyl tRNA synthetase (Jo-1) antibody	0.821	0.769-0.874	0.781	0.722-0.841
Anti-mitochondrial M2 (AMA-M2) antibody	0.895	0.844-0.947	0.920	0.883-0.957

AUC: Area under the curve.