Laparoscopic vs open radical resection in management of gallbladder carcinoma: A systematic review and meta-analysis

Table 3 Perioperative outcomes of included comparative studies

Ref.	Group	Pts	No. LNH	R0 margin(n)	Operation time (min)	Blood loss (mL)	POLS	Complications	Complications(Clavien-Dindo 3-4)
Agarwal et al[32]	LRR	24	12.5 ± 5.4	NA	270 (180-340)	200 (100-850)	5 (3-16)	3	NA
	ORR	46	12.9 ± 5.4	NA	240 (180-360)	275 (100-800)	5 (3-17)	8	NA
Feng et al[33]	LRR	41	5 ± 3	33	137 ± 92	358 ± 390	5 ± 3	3	NA
	ORR	61	5 ± 3	47	168 ± 51	386 ± 391	11 ± 5	6	NA
Itano et al[34]	LRR	16	12.6 ± 3.1	NA	368 ± 73	152 ± 90	9.1 ± 1.6	1	NA
	ORR	14	10.2 ± 4.0	NA	352 ± 75	777 ± 392	21.6 ± 9.0	3	NA
Jang et al[35]	LRR	55	7.6 ± 3.4	NA	231.0 ± 95.2	225.1 ± 328.6	5.8 ± 5.3	7	4
	ORR	44	9.9 ± 6.8	NA	252.5 ± 76.1	310.5 ± 260.9	9.5 ± 4.8	6	3
Nag et al[36]	LRR	30	11.9 ± 5.2	30	286.5 ± 71.6	158.6 ± 85.7	6.4 ± 3.1	5	0
	ORR	38	12.7 ± 4.2	37	274.2 ± 96.3	219.4 ± 87.7	9 ± 8.0	12	5
Ong et al[37]	LRR	623	NA	484	NA	NA	NA	NA	NA
	ORR	882	NA	664	NA	NA	NA	NA	NA
Vega et al[38]	LRR	65	6 (0-19)	62	240 (120-275)	300 (30-1200)	4 (2-18)	12	NA
	ORR	190	6 (0-27)	172	240 (60-600)	200 (50-2000)	6 (1-52)	38	NA
Cao et al[46]	LRR	53	6 (1-16)	NA	238.4	257 ± 6.3	10.4 ± 18.6	NA	NA
	ORR	61	8 (1-42)	NA	215.7	256.2 ± 6.3	11.3 ± 18.6	NA	NA
Dou et al[48]	LRR (PSM)	30	10.12 ± 0.90	NA	328.12 ± 21.53	256.74 ± 39.21	10.43 ± 0.97	6	3
	ORR (PSM)	30	7.92 ± 0.57	NA	245.82 ± 15.18	484.36 ± 64.67	14.23 ± 1.07	4	2
Lee et al[43]	LRR	20	5.75 ± 3.54	19	186.60 ± 88.14	320.00 ± 451.72	10.95 ± 4.82	2	2
	ORR	24	6.75 ± 4.17	23	231.67 ± 82.97	593.75 ± 912.04	12.80 ± 4.87	5	5
Navarro et al[41]	LRR (PSM)	43	6.12 ± 5.78	NA	139.05 ± 97.09	71.63 ± 178.77	6.05 ± 9.846	0	0
	ORR(PSM)	43	11.93 ± 7.03	NA	211.16 ± 91.36	208.14 ± 242.165	12.58 ± 5.504	4	0
Regmi et al[40]	LRR	20	5.4 ± 3.5	20	258.25 ± 72.50	242 ± 108.5	6.2 ± 2.4	3	NA
	ORR	30	5.8 ± 2.1	30	227.00 ± 59.81	401 ± 130.3	8.6 ± 2.3	6	NA
Huang et al[44]	LRR (PSM)	35	8.4 ± 4.6	34	245.0 (183.0-285.0)	50.0 (50.0-150.0)	6.0 (6.0-7.0)	4	1
	ORR (PSM)	35	8.1 ± 3.9	33	160.0 (125.0-230.0)	50.0 (50.0-150.0)	7.0 (6.0-8.0)	6	2
Silva et al[45]	LRR (PSM)	12	6.5 (4-9.5)	NA	237.5 (120-520)	300 (150-1750)	4.5 (2-12)	1	0
	ORR (PSM)	12	8.5 (4.5-14.5)	NA	272.5 (180-560)	275 (100-1800)	8 (5-32)	4	0
Lee et al[42]	LRR (PSM)	56	4.6 ± 4.1	NA	171.7 ± 64.1	NA	5.7 ± 4.2	4	NA
	ORR (PSM)	56	6.9 ± 4.9	NA	98.0 ± 53.2	NA	9.8 ± 4.9	7	NA
Wang et al[39]	LRR	45	19.8 ± 7.9	NA	115 ± 32.5	100 ± 25.4	3.5 ± 1.9	3	NA
	ORR	61	17.3 ± 5.7	NA	100 ± 20.4	200 ± 45.6	5.6 ± 2.7	8	NA
AlMasri et al[49]	LRR	235	6.5 ± 14.6	195	NA	NA	7.0 ± 13.0	NA	NA
	ORR	445	6.7 ± 13.5	348	NA	NA	8.8 ± 10.9	NA	NA
Cho et al[47]	LRR (PSM)	19	5.3 ± 6.6	NA	218.9 ± 145.0	NA	8.4 ± 5.9	4	0
	ORR (PSM)	19	7.3 ± 5.5	NA	316.8 ± 80.3	NA	14.4 ± 6.0	2	0

Pts: Patients; No. LNH: Number of lymph node harvested; LRR: Laparoscopic radical resection; ORR: Open radical resection; POLS: Postoperative length of stay; NA: Not available; PSM: Propensity score matching.