Laparoscopic vs open radical resection in management of gallbladder carcinoma: A systematic review and meta-analysis

Table 2 Characteristics of included comparative studies

Ref.	Year	Country	Study design	NOS	Group	Patient (n)	Age	F/M	T stage/TNM stage(n)	Follow-up (mo)
Agarwal et al[32]	2015	India	Retrospective	7	LRR	24	44 (21-61)	17/7	Ⅰ: 3; Ⅱ: 10; Ⅲ: 11	18 (6-34)
					ORR	46	49 (23-70)	34/12	Ⅰ: 5; Ⅱ: 10; Ⅲ: 31
Feng et al[33]	2019	China	Retrospective	7	LRR	41	64 ± 14	17/24	Tis: 9; T1: 10; T2: 14; T3: 8	12 (2-93)
					ORR	61	66 ± 10	22/39	Tis: 4; T1: 9; T2: 1 32; T3: 16
Itano et al[34]	2015	Japan	Retrospective	6	LRR	16	68.1 ± 19.9	7/9	T1: 3; T2: 13	37
					ORR	14	71.5 ± 13.2	9/5	T1-T2: 14	48
Jang et al[35]	2019	Korea	Retrospective	7	LRR	55	70.1 ± 8.1	36/19	T2: 55	35.2 (3-139)
					ORR	44	65.5 ± 10.5	21/23	T2: 44	38.6 (4-160)
Nag et al[36]	2019	India	Retrospective	7	LRR	30	49.6 ± 12.8	27/3	T1: 8; T2: 8; T3: 8; T4: 2	NA
					ORR	38	49 ± 10.1	23/15	T1: 6; T2: 17; T3: 15; T4: 0	NA
Ong et al[37]	2017	United States	Retrospective	6	LRR	623	70 (61-79)	442/181	T1 + T2: 461; T3: 146; UKN: 16	NA
					ORR	882		587/295	T1 + T2: 469; T3: 374; UKN: 39	NA
Vega et al[38]	2019	United StatesChile	Retrospective	8	LRR	65	68 (59-76)	49/141	T1: 14; T2: 43; T3: 8	Survivors: 70.8 (95%CI: 53.6 to 87.3)
					ORR	190		11/54	T1: 5; T2: 126; T3: 39
Cao et al[46]	2021	China	Retrospective	8	LRR	53	61 (48-77)	35	T1b: 3; T2: 50	NA
					ORR	61	64 (39-79)	47	T1b: 5; T2: 56	NA
Dou et al[48]	2022	China	Retrospective	7	LRR (PSM)	30	> 60: 21	23	T2: 9; T3: 21	NA
					ORR (PSM)	30	> 60: 19	25	T2: 10; T3: 20	NA
Lee et al[43]	2022	Korea	Retrospective	8	LRR	20	71.85 ± 9.11	15	T1: 4; T2: 12; T3: 4	NA
					ORR	24	68.08 ± 10.64	13	T1: 5; T2: 16; T3: 3	NA
Navarro et al[41]	2020	Korea	Retrospective	7	LRR (PSM)	43	66.7 ± 10.3	18	T2: 43	32 (2-125)
					ORR (PSM)	43	65.4 ± 7.6	15	T2: 43
Regmi et al[40]	2020	China	Retrospective	7	LRR	20	> 70y: 4	13	T1b: 10; T2: 10	21.28 (12-29)
					ORR	30	> 70y: 3	19	T1b: 13; T2: 17	20.4 (12.25-29.50)
Huang et al[44]	2022	China	Retrospective	8	LRR (PSM)	35	58.7 ± 10.5	19	T3: 35	NA
					ORR (PSM)	35	60.4 ± 10.6	18	T3: 35	NA
D'Silva et al[45]	2021	China	Retrospective	7	LRR (PSM)	12	68.5 ± 10.56	7	T2: 7;T3: 9	21.5 (9-80)
					ORR (PSM)	12	67.5 ± 12.88	7	T2: 5;T3: 3
Lee et al[42]	2022	Korea	Retrospective	8	LRR (PSM)	56	62.0 ± 13.7	27	T2: 56	26.2
					ORR (PSM)	56	62.5 ± 15.0	28	T2: 56
Wang et al[39]	2020	China	Retrospective	8	LRR	45	62.6 (45-76)	29	Tb: 30; T2: 15	38 (3-84)
					ORR	61	65.2 (51-82)	37	Tb: 35;T2: 26	33 (6-72)
AlMasri et al[49]	2020	United States	Retrospective	8	LRR	235	66.1 ± 11.8	64	I: 24; II: 78; III: 133	NA
					ORR	445	65.8 ± 11.2	294	I: 29; II: 114; III: 302	NA
Cho et al[47]	2022	Korea	Retrospective	7	LRR (PSM)	19	69.9 ± 9.1	11	T2: 19	26
					ORR (PSM)	19	66.7 ± 7.8	7	T2: 19	70

UKN: Unknown; LRR: Laparoscopic radical resection; ORR: Open radical resection; PSM: Propensity score matching; NOS: The modified Newcastle–Ottawa scale; TNM: Tumor-node-metastasis; NA: Not available; F: Female; M: Male; CI: Confidence interval.