Multinucleated giant cells of bladder mucosa are modified telocytes: Diagnostic and immunohistochemistry algorithm and relation to PD-L1 expression score

Figure 3 Conventional histological examination of urothelial carcinoma of the bladder. A: Presence of atypical mono-, bi- and multin urothelial carcinoma (UC) leated giant fibroblast-like stromal cells (arrow) in the vesicular lamina propria adjacent to non-invasive papillary low-grade (LG) UC. A nonspecific stromal inflammatory response rich in plasma cells and eosinophilic leukocytes accompany them. hematoxylin-eosin, 400 ×; B: Presence of multinucleated giant cells in the bladder lamina propria (arrow) in close proximity to tertiary lymphoid structures of type 2 and 3 (2^nd and 3^rd degree) and with non-invasive papillary LG UC. hematoxylin-eosin, 100 ×.