Case Report
Copyright ©The Author(s) 2023.
World J Clin Cases. Sep 16, 2023; 11(26): 6252-6261
Published online Sep 16, 2023. doi: 10.12998/wjcc.v11.i26.6252
Table 3 Relevant therapeutics for gene MRE11
Drug name
Tumor entity
Approval
Approval limited to biomarkers/others
Approval in combination with other drugs
Niraparib, PARP inhibitorProstate cancerEMABRCA1, BRCA2Abiraterone
Olaparib, PARP inhibitorFallopian tube carcinomaEMAHRDBevacizumab
Olaparib, PARP inhibitorFallopian tube carcinomaFDAHRDBevacizumab
Olaparib, PARP inhibitorOvarian cancerEMACancer associated with HRDBevacizumab
Olaparib, PARP inhibitorOvarian cancerFDAHRDBevacizumab
Olaparib, PARP inhibitorPrimary peritoneal carcinomaEMACancer associated with HRDBevacizumab
Olaparib, PARP inhibitorPrimary peritoneal carcinomaFDAHRDBevacizumab
Olaparib, PARP inhibitorProstate cancerEMAAdult patients, metastatic castraction- resitant cancer, chemotherapy not indicatedAbiraterone, prednisone
Olaparib, PARP inhibitorProstate cancerFDABRCA1, BRCA2Abiraterone, prednisone