Predictive value of preoperative albumin-bilirubin score and other risk factors for short-term outcomes after open pancreatoduodenectomy

Table 4 Factors associated with postoperative pancreatic fistula (univariate logistic regression), n (%)

	No POPF (n = 264)	POPF (n = 83)	OR (95%CI)	P value
Male gender	140 (53)	53 (63.9)	1.56 (0.94-2.6)	0.085
Age (yr), median (IQR)	68 (61-75.5)	70 (64-76)	1.01 (0.99-1.03)	0.478
BMI, median (IQR)	24.8 (22.2-27.9)	26 (23.5-29.8)	1.08 (1.02-1.15)	0.008
ASA score
1	9 (3.4)	1 (1.2)	1
2	101 (38.3)	35 (42.2)	3.12 (0.38-25.51)	0.289
3	152 (57.6)	45 (54.2)	2.66 (0.33-21.6)	0.359
4	2 (0.8)	2 (2.4)	9 (0.52-155.24)	0.130
ALBI score	-2.6 (-3.0 to -2.0)	-2.6 (-3.0 to -1.9)	1.13 (0.78-1.62)	0.520
Operation type
PPPD	129 (48.9)	46 (55.4)	1
Whipple	135 (51.1)	37 (44.6)	0.77 (0.47-1.26)	0.298
Somatostatin use	135 (51.1)	50 (60.2)	1.45 (0.88-2.39)	0.148
Soft pancreatic texture	104 (44.4)	60 (82.2)	5.77 (3.00-11.08)	< 0.001
Blood loss (mL), median (IQR)	400 (250-560)	400 (300-600)	1.02 (0.98-1.05)	0.356
Pathology
Pancreatic carcinoma	144 (54.5)	26 (31.3)	0.38 (0.23-0.64)	< 0.001
Bile duct carcinoma	20 (7.6)	16 (19.3)	2.91 (1.43-5.93)	0.003
Duodenal carcinoma	3 (1.1)	6 (7.2)	6.78 (1.66-27.74)	0.008
Ampullary carcinoma	34 (12.9)	12 (14.5)	1.14 (0.56-2.33)	0.712
NET	20 (7.6)	7 (8.4)	1.12 (0.46-2.76)	0.799
IPMN	11 (4.2)	5 (6.0)	1.47 (0.50-4.37)	0.484

POPF: Postoperative pancreatic fistula; OR: Odds ratio; IQR: Interquartile range; BMI: Body mass index; ALBI: Albumin-bilirubin; ASA score: American Society of Anesthesiologists score; PPPD: Pylorus-preserving pancreatoduodenectomy; NET: Neuroendocrine tumour; IPMN: Intraductal papillary mucinous neoplasm.