Clinicopathological study of malignant peripheral nerve sheath tumors in the head and neck: Case reports and review of literature

Figure 2 Histological characteristics of malignant peripheral nerve sheath tumor (MPNST) and immunohistochemical analysis of H3K27me3 in MPNST sections. A: The lesion cells display predominantly spindle in an architectural pattern; B: The cells are enlongated and tends to be hyperchromatic with scant cytoplasm; C: There is severe cytologic atypia and nuclear pleomorphism, with focally brisk mitotic activity; D: Complete loss of H3K27me3 expression on sections. Staining of blood vessels and inflammatory cells is the internal positive controls; E: Partial loss of H3K27me3 expression on the section; F: Strong expression of H3K27me3 is retained in some MPNST cases. Scale bars: 50 μm.