Hypopharyngeal cancer trends in a high-incidence region: A retrospective tertiary single center study

Table 1 Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx, as stated by European Head and Neck Society-European Society for Medical Oncology-European Society of Radiotherapy & Oncology Clinical Practice guidelines for diagnosis, treatment and follow-up-management of hypopharyngeal cancer (Stage I-IV B)

TNM Stage	Standard	Option
cT1-2 cN0 cM0	RT
	Conservation larynx surgery (T and N), followed by RT and CRT if indicated
cT1-2 cN1-3 M0; cT3 cN0-3 M0	Concomitant CRT	Surgery followed by RT or CRT if indicated
	If laryngectomy necessary, concomitant CRT (T and N), or induction ChT followed by RT (T and N) in case of complete or partial response after induction or surgery in case of stable or progressive disease after induction
cT4a cN0-3 cM0	Surgery (T and N), followed by RT or CRT if indicated	CRT
		Induction ChT followed by RT (T and N) in case of complete or partial response after induction or surgery (T and N) in case of stable or progressive disease after induction
cT4b cN0-3 cM0		Induction ChT followed by RT for responders (T and N)
		Concomitant CRT
		Palliative treatment: systemic ChT/ immunotherapy and/or palliative RT and/or BSC

BSC: Best supportive care; ChT: Chemotherapy; CRT: Chemoradiotherapy; M: Metastasis; N: Node; RT: Radiotherapy; T: Tumor; TNM: Tumor, node, metastasis.