Reduction rate of monoclonal protein as a useful prognostic factor in standard-risk group of newly diagnosed multiple myeloma

Table 2 Univariate analysis of progression-free survival and overall survival

Prognostic factor	PFS		OS
	HR (95%CI)	P value	HR (95%CI)	P value
Age (yr)	1.051 (1.031-1.071)	≤ 0.001	1.034 (1.012-1.055)	0.002
Gender	1.265 (0.828-1.931)	0.277	1.412 (0.926-2.152)	0.109
Classification	1.037 (0.949-1.132)	1.037	1.093 (0.999-1.196)	0.053
ISS stage	1.718 (1.247-2.366)	0.001	2.093 (1.520-2.883)	≤ 0.001
DS stage	2.094 (1.082-4.054)	0.028	1.982 (1.015-3.869)	0.045
GPT	1.011 (1.002-1.021)	0.019	1.009 (0.999-1.019)	0.082
GOT	1.022 (1.011-1.033)	≤ 0.001	1.025 (1.013-1.038)	≤ 0.001
CRP	1.002 (0.996-1.007)	0.593	1.002 (0.996-1.008)	0.491
A/G	1.041 (0.698-1.553)	0.844	1.149 (0.754-1.751)	0.518
LDH	1.003 (1.001-1.004)	≤ 0.001	1.003 (1.002-1.005)	≤ 0.001
t(6;14)	1.021 (0.319-3.266)	0.972	1.285 (0.399-4.134)	0.674
t(11;14)	1.149 (0.281-4.708)	0.847	1.188 (0.290-4.871)	0.811
Platelet count	9.604 (4.965-18.578)	≤ 0.001	8.437 (4.528-15.721)	≤ 0.001
Herpes	0.821 (0.451-1.495)	0.52	0.908 (0.498-1.653)	0.751
Chemotherapy regimen	1.005 (0.856-1.180)	0.952	0.949 (0.795-1.133)	0.564
Autotransplantation	0.339 (0.137-0.842)	0.020	0.347 (0.140-0.860)	0.022
TC	0.773 (0.631-0.947)	0.013	0.757 (0.617-0.927)	0.007
TG	0.861 (0.666-1.114)	0.255	0.846 (0.642-1.113)	0.232
P	1.143 (0.953-1.370)	0.15	1.113 (0.934-1.325)	0.232
C1 reduction rate	0.412 (0.325-0.521)	≤ 0.001	0.438 (0.346-0.554)	≤ 0.001
C2 reduction rate	0.412 (0.325-0.523)	≤ 0.001	0.441 (0.351-0.553)	≤ 0.001
C3 reduction rate	0.390 (0.303-0.501)	≤ 0.001	0.377 (0.290-0.490)	≤ 0.001
C4 reduction rate	0.358 (0.283-0.455)	≤ 0.001	0.345 (0.267-0.445)	≤ 0.001

PFS: Progression-free survival; OS: Overall survival; HR: Hazard Ratio; 95%CI: 95% confidence interval; ISS: International Staging System; DS: Durie-Salmon; GPT: Glutamic-pyruvic transaminase; GOT: Glutamic-oxaloacetic transaminase; CRP: Catabolite activator protein; A/G: Albumin/globulin; LDH: Lactate dehydrogenase; T: translocation; TC: Total cholesterol; TG: Triglyceride; P: Phosphorous; C1: The first cycle; C2: The second cycle; C3: The third cycle; C4: The fourth cycle.