Reduction rate of monoclonal protein as a useful prognostic factor in standard-risk group of newly diagnosed multiple myeloma

Table 1 Baseline characteristics of multiple myeloma patients with a reduction rate of monoclonal protein after first and fourth cycles of chemotherapy

Characteristic	C1 reduction rate		P value	C4 reduction rate		P value
	< 50	≥ 50		< 75	≥ 75
Age (yr)			≤ 0.001			0.003
< 65	25	56		21	60
≥ 65	49	34		40	43
Gender			0.912			0.903
Male	36	43		37	42
Female	38	47		39	46
ISS stage			≤ 0.001			≤ 0.001
I	5	39		2	42
II	31	34		23	42
III	38	17		36	19
DS stage			0.087			0.783
I	1	1		1	1
II	7	20		9	19
III	66	70		51	83
GPT			0.657			0.985
≤ 40	71	85		58	98
> 40	3	5		3	5
GOT			0.510			0.617
≤ 40	67	84		57	94
> 40	7	6		4	9
CRP			0.704			0.880
≤ 10	53	62		42	83
> 10	21	28		19	20
A/G			0.916			0.041
≤ 0.5	29	36		18	47
> 0.5	45	54		43	56
LDH			0.215			0.530
≤ 245	54	73		46	82
> 245	20	17		15	21
t(6;14)	3	3	1.000	2	4	0.405
t(11;14)	2	2	1.000	1	3	0.615
Platelet count			≤ 0.001			≤ 0.001
≥ 100	55	88		45	98
< 100	19	2		16	5
Herpes	13	19	0.569	9	23
Autotransplantation	5	20	0.006	5	20	0.020
TC (mmol/L)			0.903			0.767
< 5.2	63	76		52	86
≥ 5.2	11	14		9	17
TG (mmol/L)			0.546			0.778
< 1.71	51	58		41	67
≥ 1.71	23	32		20	36
P (mmol/L)			0.587			0.568
< 1.07	17	24		13	26
≥ 1.07	57	66		48	77

C1: The first cycle; C4: The fourth cycle; ISS: International Staging System; DS: Durie-Salmon; GPT: Glutamic-pyruvic transaminase; GOT: Glutamic-oxaloacetic transaminase; CRP: Catabolite activator protein; A/G: Albumin/globulin; LDH: Lactate dehydrogenase; T: Translocation; TC: Total cholesterol; TG: Triglyceride; P: Phosphorous.