Identification of key genes and biological pathways in lung adenocarcinoma by integrated bioinformatics analysis

doi:10.12998/wjcc.v11.i23.5504

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

World J Clin Cases. Aug 16, 2023; 11(23): 5504-5518
Published online Aug 16, 2023. doi: 10.12998/wjcc.v11.i23.5504

Table 2 Data obtained using CytoHubba and CytoNCA

	Gene symbol	Betweenness centrality (≥ 50)	Gene symbol	Degree (≥ 10)
1	CDH1	611.39685	CDH1	34
2	TOP2A	167.13333	TOP2A	16
3	CD19	166.32063	CRABP2	12
4	FCRL2	117.73333	MMP13	12
5	CRABP2	96.13333	MMP12	12
6	MYO6	78.28889	CXCL14	12
7	SFRP4	62.00000	CD19	10
8	ADAM8	62.00000	LTF	10
9	SRGAP1	56.266666	-	-
10	MMP12	51.720634	-	-

ADAM8: ADAM metallopeptidase domain 8; CDH1: Cadherin 1; CRABP2: Cellular retinoic acid binding protein 2; CXCL14: C-X-C motif chemokine ligand 14; FCRL2: Fc receptor like 2; LTF: Lactotransferrin; MMP12/13: Matrix metallopeptidase 12/13; MYO6: Myosin VI; SFRP4: Secreted frizzled related protein 4; SRGAP1: SLIT-ROBO Rho GTPase activating protein 1; TOP2A: DNA topoisomerase II alpha.

Citation: Zhang L, Liu Y, Zhuang JG, Guo J, Li YT, Dong Y, Song G. Identification of key genes and biological pathways in lung adenocarcinoma by integrated bioinformatics analysis. World J Clin Cases 2023; 11(23): 5504-5518
URL: https://www.wjgnet.com/2307-8960/full/v11/i23/5504.htm
DOI: https://dx.doi.org/10.12998/wjcc.v11.i23.5504