Meta-analysis of outcomes from drug-eluting stent implantation in infrapopliteal arteries

Table 1 Main characteristics and baselines of the included studies

Ref.	Design	Coutry/Registry	Enrollment period	Drug on DES	Control	Optimal stentinga	Num of patients	Mean age (yr)	Male (%)	Num of limbs	Num of arteries	Num of lesions	Median RC	Mean LRD (mm)	Mean LL (mm)	CTO (%)	Follow up period (yr)b
Siablis et al[42], 2009	PCS	Greece	NA	S	PTA+BMSI	N vs N	62 vs 41	69 vs 72	71 vs 90	75 vs 47	NA	153 vs 77	5 vs 5	NA	55 vs 45	25 vs 35	1
Karnabatidis et al[44], 2011	ACS	Greece	2006-2009	S	PTA+BMSI	Y vs N	47 vs 34	71 vs 71	74 vs 82	51 vs 36	75 vs 57	102 vs 72	4 vs 5	NA	76 vs 77	17 vs 35	1
Scheinert et al[45], 2012	RCT	ACHILLES	2008-2010	S	PTA±BMSI	Y vs N	99 vs 101	72 vs 74	68 vs 75	NA	NA	113 vs 115	4 vs 4	2.6 vs 2.6	27 vs 27	81 vs 75	1
Rastan et al[26], 2012	RCT	Germany	2006-2008	S	PTA+BMSI	Y vs Y	82 vs 79	73 vs 72	68 vs 65	NA	NA	82 vs 79	4 vs 3	3.0 vs 3.0	30 vs 31	23 vs 22	3
Bosiers et al[43], 2012	RCT	DESTINY	2008-2009	E	PTA+BMSI	Y vs Y	74 vs 66	75 vs 76	61 vs 58	78 vs 76	78 vs 76	78 vs 76	4.5 vs 5	3.0 vs 2.9	16 vs 19	15 vs 17	1
Spreen et al[24], 2017	RCT	PADI	2007-2013	P	PTA±BMSI	Y vs N	73 vs 64	74 vs 73	67 vs 73	74 vs 66	NA	121 vs 91	5 vs 5	2.9 vs 2.9	21 vs 23	NA	3
Konijn et al[25], 2020	RCT	PADI	2007-2013	P	PTA±BMSI	Y vs N	73 vs 64	74 vs 73	67 vs 73	74 vs 66	NA	121 vs 91	5 vs 5	2.9 vs 2.9	21 vs 23	NA	10
Zuzek et al[27], 2022	RCS	USA	2016-2017	NA	PTA+BMSI	NA	1056 vs 761	72 vs 72	59 vs 64	NA	NA	NA	5 vs 5	NA	NA	NA	0.5

^aDES implantation was performed regardless of whether predilatation was performed or the outcome of predilatation.

^bApproximate mean. The data variables of double arms are presented in the form of "DES vs control".

PCS: Prospective cohort study; ACS: Ambispective cohort study; RCT: Randomized controlled trial; RCS: Retrospective cohort study; NA: Not available; DES: Drug-eluting stent; S: Sirolimus; E: Everolimus; P: Paclitaxel; PTA: Percutaneous transluminal angioplasty; BMSI: Bare metal stent implantation; N: No; Y: Yes; Num: Number; RC: Rutherford classification; LRD: Lesion reference diameter; LL: Lesion length; CTO: Chronic total occlusion.