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©The Author(s) 2023.
World J Clin Cases. Aug 6, 2023; 11(22): 5193-5203
Published online Aug 6, 2023. doi: 10.12998/wjcc.v11.i22.5193
Published online Aug 6, 2023. doi: 10.12998/wjcc.v11.i22.5193
Cancer type | Sonosensitizer | Therapeutic parameters | Result | Ref. |
Glioma | Ce6 | 0.6 W/cm2, 60 s | SDT inhibits xenograft tumor growth by inducing apoptosis and inhibiting mitochondrial autophagy | [80] |
Breast cancer | Mn-MOF | 1.0 MHz, 0.9 W/cm2, 30% duty cycle | Mn-MOF catalyzes the in situ production of O2 to alleviate tumor hypoxia and reduce GSH and GPX4, which contributes to ROS formation and iron death, thereby killing cancer cells | [81] |
Melanoma | Ce6 | 2.0 MHz, 2.0 W/cm2, 20% duty cycle | The combination of SDT and aPD-L1 immunotherapy effectively inhibits tumor infiltration and promotes activation of cytotoxic T cells, resulting in strong anticancer immunity and long-term immune memory, effectively inhibiting melanoma growth | [82] |
Pancreatic cancer | Hematoporphyrin | 1.0 MHz, 3.0 W/cm2, 50% duty cycle | SDT exerts antitumor effects by suppressing the expression of immunosuppressive T-cell phenotypes | [83] |
Cervical cancer | IR780 | 2.5W/cm2, 20 s | IR780 selectively positions the nanoparticles into the mitochondria of cancer cells, and generates the acoustic droplet vaporization effect after perfluorohexane phase transition to achieve the synergistic treatment of tumors | [84] |
Ovarian cancer | ICG | 1.0 W/cm2, 1 min | SDT in combination with PDT and oxaliplatin can increase antitumor effects, enhance immunological potency and improve dual-mode imaging | [85] |
Prostate cancer | hematoporphyrin | 1.0 MHz, 3.5 W/cm2, 30% duty cycle, 3.5 mim | pH- and histone B-responsive nanoparticles combined with SDT have a significant induced cytotoxic effect on prostate cancer cells and can effectively treat cancer | [86] |
Gastric cancer | Pyropheophorbide-lipid | 1.0 MHz, 1.0 W/cm2, 50% duty cycle, 3 min | Construction of an ultrasound microbubble using pyrophosphorylated lipids in combination with trastuzumab for the synergistic treatment of HER2-positive gastric cancer with sonodynamic therapy and antibody therapy | [87] |
Lung cancer | DVDMS | 0.5MHz, 0.5 W/cm2, 10% duty cycle, 5 min | DVDMS in combination with SDT exerts antitumor effects via the mitochondria-mediated apoptosis signaling pathway and the extrinsic apoptosis pathway | [88] |
- Citation: Dong HQ, Fu XF, Wang MY, Zhu J. Research progress on reactive oxygen species production mechanisms in tumor sonodynamic therapy. World J Clin Cases 2023; 11(22): 5193-5203
- URL: https://www.wjgnet.com/2307-8960/full/v11/i22/5193.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v11.i22.5193