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Copyright ©The Author(s) 2023.
World J Clin Cases. Aug 6, 2023; 11(22): 5193-5203
Published online Aug 6, 2023. doi: 10.12998/wjcc.v11.i22.5193
Table 1 Application of sonodynamic therapy in different tumors
Cancer type
Sonosensitizer
Therapeutic parameters
Result
Ref.
GliomaCe60.6 W/cm2, 60 sSDT inhibits xenograft tumor growth by inducing apoptosis and inhibiting mitochondrial autophagy[80]
Breast cancerMn-MOF1.0 MHz, 0.9 W/cm2, 30% duty cycleMn-MOF catalyzes the in situ production of O2 to alleviate tumor hypoxia and reduce GSH and GPX4, which contributes to ROS formation and iron death, thereby killing cancer cells[81]
MelanomaCe62.0 MHz, 2.0 W/cm2, 20% duty cycleThe combination of SDT and aPD-L1 immunotherapy effectively inhibits tumor infiltration and promotes activation of cytotoxic T cells, resulting in strong anticancer immunity and long-term immune memory, effectively inhibiting melanoma growth[82]
Pancreatic cancerHematoporphyrin1.0 MHz, 3.0 W/cm2, 50% duty cycleSDT exerts antitumor effects by suppressing the expression of immunosuppressive T-cell phenotypes[83]
Cervical cancerIR7802.5W/cm2, 20 sIR780 selectively positions the nanoparticles into the mitochondria of cancer cells, and generates the acoustic droplet vaporization effect after perfluorohexane phase transition to achieve the synergistic treatment of tumors[84]
Ovarian cancerICG1.0 W/cm2, 1 minSDT in combination with PDT and oxaliplatin can increase antitumor effects, enhance immunological potency and improve dual-mode imaging[85]
Prostate cancerhematoporphyrin1.0 MHz, 3.5 W/cm2, 30% duty cycle, 3.5 mimpH- and histone B-responsive nanoparticles combined with SDT have a significant induced cytotoxic effect on prostate cancer cells and can effectively treat cancer[86]
Gastric cancerPyropheophorbide-lipid1.0 MHz, 1.0 W/cm2, 50% duty cycle, 3 minConstruction of an ultrasound microbubble using pyrophosphorylated lipids in combination with trastuzumab for the synergistic treatment of HER2-positive gastric cancer with sonodynamic therapy and antibody therapy[87]
Lung cancerDVDMS0.5MHz, 0.5 W/cm2, 10% duty cycle, 5 minDVDMS in combination with SDT exerts antitumor effects via the mitochondria-mediated apoptosis signaling pathway and the extrinsic apoptosis pathway[88]