Systematic review of fibroblastic rheumatism: A case report

Table 4 Key points of differential diagnosis between various similar diseases

	RA	PsA	MCRH	NS	FR
Clinical features
Skin
Sclerodactyly	+/-	-	-	+	+
Subcutaneous nodules	+	-	+	-	+
Raynaud phenomenon	+	-	-	-	+
Musculoskeletal
Favorite sites
DIP	-	+	+	+	+
PIP	+	+	+	+	+
MCP	+	+/-	+	+/-	+
Histopathologic features
Proliferation of fibroblasts	-	-	-	+	+
Proliferation of collagen fibers	-	-	-	+	+
Multinucleated giant cells	-	+	+	+	+/-
Synovitis	+	+	+	+/-	+
Loss of elastin	-	-	+	-	+
Immunohistochemistry
CD34	+/-	+	+/-	+	+/-
SMA	-	+/-	+/-	+/-	+
Vimentin	-	-	-	-	+
C3	+	+	+/-	+/-	-
Other features
Elevation of CRP and/or ESR	+	+	+/-	+	-
Rheumatoid factor	+	-	-	+/-	-
Redness and swelling	+	+/-	-	+/-	+

RA: Rheumatoid arthritis; PsA: Psoriatic arthritis; NS: Nodular scleroderma; MCRH: Multicentric reticulohistiocytosis; FR: Fibroblastic rheumatism; DIP: Distal interphalangeal joint; PIP: Proximal interphalangeal joint; MCP: Metacarpophalangeal joints; SMA: Smooth muscle actin; CRP: C-reactive protein; ESR: Erythrocyte sediment rate.