Manipulation of the intestinal microbiome-a slow journey to primetime

Table 1 Summary of pre-stool donation screening requirements and exclusion criteria based on Medical Circular of the Ministry of Health, Israel, date December 2022[107]

Pre stool donation screening	Exclusion criteria for stool donation
Current illness or exposure to endemic illness in the last 6 mo	Viral or bacterial illness in the week prior to donation, persistent fever, a visit in the last 6 mo to a country with an endemic infectious disease including parasitic diseases and traveler’s diarrhea
Malignancy or gastrointestinal disease	Malignant disease (current or past), personal or family history of inflammatory bowel disease, personal history of IBS or symptoms of IBS, or celiac disease
Hepatitis risk and the risk of sexually transmitted infection	Tattoo or piercing or blood transfusion within 6 mo prior to donation, casual unprotected sexual intercourse within 3 mo prior to donation or previous sexual contact with an intravenous drug user or sex worker. Sexual contact with a person infected with HTLV or HIV or hepatitis in the previous 6 mo
Chronic disease	Chronic liver disease, neurological or autoimmune or rheumatological or hematological or metabolic or endocrine (aside from Hashimoto’s disease) or heart or lung or atopic disease. Chronic pain or chronic fatigue syndromes. Previous malaria diagnosis or rare infectious disease
Surgical history	Previous gastrointestinal surgery, recipient of transplanted tissue
Medication history	Any long-term medication use or short-term use of immunosuppressive medication or probiotics, antibiotics use within the previous 6 mo, current or previous chemotherapy, previous recipient of growth hormone or recipient of a live attenuated virus injection in the last 3 mo
Illicit drug history	Previous illicit drug use (mariuana is an exclusion only if used within 3 mo of donation)

HTLV: Human T lymphocytic virus; HIV: Human immunodeficiency virus; IBS: Irritable bowel syndrome.