High expression of autophagy-related gene EIF4EBP1 could promote tamoxifen resistance and predict poor prognosis in breast cancer

Figure 1 Eukaryotic translation initiation factor 4E binding protein 1 was upregulated, which correlated with poor survival in tamoxifen-resistant breast cancer cells. A and B: Box diagram showed that eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) was upregulated in tamoxifen-resistant breast cancer cells in GSE21618 and GSE26459; C: Overall survival of EIF4EBP1 analysis by Gene Expression Profiling Interactive Analysis; D: Disease-free survival of EIF4EBP1 by Gene Expression Profiling Interactive Analysis; E: Overall survival of EIF4EBP1 by Kaplan-Meier plotter; F: Disease-free survival of EIF4EBP1 by Kaplan-Meier plotter; G: Post-progression survival of EIF4EBP1 by Kaplan-Meier plotter; H: Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis of EIF4EBP1 by GSEA; I: EIF4EBP1 was upregulated in tamoxifen-resistant breast cancer cells and confirmed by real-time reverse transcription polymerase chain reaction; J: EIF4EBP1 was upregulated in breast cancer tissues and confirmed by real-time reverse transcription polymerase chain reaction. Error bars represent means ± standard deviations of triplicate analyses. ^aP < 0.05. EIF4EBP1: Eukaryotic translation initiation factor 4E binding protein 1; HR: Hazard ratio.