Retrospective Study
Copyright ©The Author(s) 2023.
World J Clin Cases. Jul 16, 2023; 11(20): 4852-4864
Published online Jul 16, 2023. doi: 10.12998/wjcc.v11.i20.4852
Table 2 Comparison of clinical and pathological characteristics among different patients
Imaging/pathological featuresTraining group
Validation group
M+group (n = 40)
M- group (n = 186)
Statistical value
P value
M+ group (n = 17)
M- group (n = 80)
Statistical value
P value
Age56.154 ± 13.53759.008 ± 10.3780.0630.20065.87 ± 9.3155.98 ± 10.630.080.20
Group
    BCS19 (47.5)185 (99.5)χ2 = 66.874< 0.0018 (47.1)78 (97.5)χ2 = 29.32< 0.001
    Non-BCS21 (52.5)1 (0.5)9 (52.9)2 (2.5)
MRI
    Lesion type
       Mass15 (37.5)87 (46.8)χ2 = 42.153< 0.0018 (47.1)54 (67.5)χ2 = 12.782< 0.001
       NME1 (2.5)11 (5.9)χ2 = 19.263< 0.0010 (0)1 (12.5)χ2 = 1.1910.275
       Mass + NME8 (20.0)38 (20.4)χ2 = 14.719< 0.0013 (17.6)6 (75.0)χ2 = 3.5250.060
       Mass + Mass16 (40.0)50 (26.9)χ2 = 8.8470.0036 (35.3)14 (17.5)χ2 = 1.7940.180
    MIP_TRA
       Linear10 (25.0)76 (40.9)χ2 = 0.8160.3661 (5.9)26 (32.5)χ2 = 1.5750.209
       Multiple punctate18 (45.0)4 (2.2)χ2 = 34.67< 0.0018 (47.0)4 (5.0)χ2 = 1.1660.280
       Symmetric5 (12.5)27 (14.5)χ2 = 0.6870.4073 (5.9)8 (10.0)χ2 < 0.0011.000
       None7 (17.5)79 (42.5)χ2 = 2.9860.0845 (29.4)42 (52.5)χ2 < 0.0011.000
    Enhancement
       Heterogeneous29 (72.5)146 (78.5)χ2 = 0.0390.84316 (86.7)59 (73.8)χ2 = 0.5540.457
       Homogeneous8 (20.0)29 (15.6)χ2 = 0.0750.7841 (6.7)17 (21.3)χ2 = 0.7600.383
       Rim enhancement3 (7.5)11 (5.9)χ2 = 0.0050.9420 (6.7)4 (5.0)χ2 < 0.0011.000
    Tumor size2.5 (1.1, 6.0)2.08 (0.50, 5.40)0.0990.0012.27 (1.3, 5.0)1.95 (0.80, 6.70)χ2 = 0.751< 0.001
    Time_Intensity_Curve
       Type I3 (7.5)29 (15.6)χ2 = 1.6190.2032 (11.8)20 (25.0)χ2 < 0.0011.000
       Type II7 (17.5)61 (32.8)χ2 = 0.0780.7808 (47.1)25 (31.3)χ2 = 0.1330.715
       Type III30 (75.0)96 (51.6)χ2 = 20.197< 0.0017 (41.2)35 (43.8)χ2 = 0.5120.474
    Margin
       Clear3 (7.5)21 (11.29)χ2 < 0.0011.0002 (11.8)10 (12.5)χ2 = 0.0250.875
       Unclear8 (20.0)28 (15.05)χ2 = 0.0280.8685 (29.4)16 (20.0)χ2 = 0.0880.767
       Spiculated29 (72.5)137 (73.66)χ2 = 0.0890.76610 (58.8)54 (67.5)χ2 < 0.0011.000
    Shape
       Irregular30 (75)111 (59.7)χ2 = 0.2940.58814 (82.4)53 (66.3)χ2 = 7.3350.007
       Roundish5 (12.5)59 (31.7)χ2 = 0.5450.4603 (17.6)19 (23.8)χ2 = 5.0580.025
       Multiple nodules5 (12.5)16 (8.6)χ2 < 0.0011.0000 (0.0)8 (10.0)χ2 = 0.3010.583
MT
    Tumor shape
       High_Density_Nodule1 (2.5)9 (4.8)χ2 < 0.0011.0000 (0.0)8 (10.0)χ2 < 0.0011.000
       Regular mass21 (52.5)113 (60.8)χ2 = 3.4360.06413 (76.5)46 (57.5)χ2 = 9.5290.002
       Irregular mass3 (7.5)35 (18.8)χ2 = 0.0560.8134 (23.5)13 (16.3)χ2 = 11.0540.001
       Undetected15 (37.5)29 (15.6)χ2 = 5.5650.0182 (11.8)13 (16.3)χ2 = 2350.628
    Margin
       Clear6 (15.0)24 (12.9)χ2 = 1.1080.2923 (17.6)13 (16.3)χ2 = 0.5900.442
       Unclear10 (25.0)83 (44.6)χ2 < 0.0010.9937 (41.2)37 (46.3)χ2 < 0.0011.000
       Spiculated9 (22.5)62 (33.3)χ2 = 0.4360.5095 (29.4)24 (30.0)χ2 < 0.0011.000
       Undetected15 (37.5)17 (9.14)χ2 = 5.5650.0182 (11.8)6 (7.50)χ2 = 0.2350.628
US
    Margin
       Clear18 (45.0)55 (29.6)χ2 = 0.6040.4373 (17.6)19 (23.8)χ2 = 0.1170.733
       Unclear10 (25.0)72 (38.7)χ2 = 1.0840.2989 (52.9)40 (50.0)χ2 = 0.0010.977
       Spiculated9 (22.5)59 (31.7)χ2 = 0.0960.7565 (29.4)21 (26.3)χ2 = 0.0090.926
    Multifocality
       Multifocality10 (25.0)29 (9.0)χ2 = 0.3830.5364 (23.5)10 (12.5)χ2 < 0.0011.000
       Univocality30 (75.0)157 (91.0)13 (76.5)70 (87.5)
ER
    Positive31 (77.5)163 (87.6)χ2 = 4.8660.02715 (88.2)71 (88.8)χ2 = 0.3010.583
    Negative9 (22.5)23 (12.4)2 (11.8)9 (11.3)
PR
    Positive30 (73.1)145 (78.0)χ2 = 0.8640.35314 (82.4)67 (83.8)χ2 = 0.2950.587
    Negative10 (26.9)41 (22.0)3 (17.6)13 (16.3)
Molecular subtypes
    Luminal A9 (22.5)64 (34.4)χ2 = 0.5450.4601 (6.7)31 (38.8)χ2 = 0.6430.423
    LuminalB_Her2(-)16 (40.0)70 (37.6)χ2 = 0.1520.6968 (47.1)33 (41.3)χ2 = 2.3630.124
    LuminalB_Her2(+)5 (12.5)29 (15.6)χ2 = 0.4100.5225 (29.4)9 (11.3)χ2 < 0.0011.000
    HER2_enriched6 (15.0)6 (3.2)χ2 = 9.5490.0022 (11.8)4 (5.0)χ2 < 0.0011.000
    TNBC4 (10.0)17 (9.1)χ2 = 0.0080.9280 (0.0)3 (3.8)χ2 = 0.0890.766