Copyright
©The Author(s) 2023.
World J Clin Cases. Jul 16, 2023; 11(20): 4852-4864
Published online Jul 16, 2023. doi: 10.12998/wjcc.v11.i20.4852
Published online Jul 16, 2023. doi: 10.12998/wjcc.v11.i20.4852
Imaging/pathological features | Training group | Validation group | ||||||
M+group (n = 40) | M- group (n = 186) | Statistical value | P value | M+ group (n = 17) | M- group (n = 80) | Statistical value | P value | |
Age | 56.154 ± 13.537 | 59.008 ± 10.378 | 0.063 | 0.200 | 65.87 ± 9.31 | 55.98 ± 10.63 | 0.08 | 0.20 |
Group | ||||||||
BCS | 19 (47.5) | 185 (99.5) | χ2 = 66.874 | < 0.001 | 8 (47.1) | 78 (97.5) | χ2 = 29.32 | < 0.001 |
Non-BCS | 21 (52.5) | 1 (0.5) | 9 (52.9) | 2 (2.5) | ||||
MRI | ||||||||
Lesion type | ||||||||
Mass | 15 (37.5) | 87 (46.8) | χ2 = 42.153 | < 0.001 | 8 (47.1) | 54 (67.5) | χ2 = 12.782 | < 0.001 |
NME | 1 (2.5) | 11 (5.9) | χ2 = 19.263 | < 0.001 | 0 (0) | 1 (12.5) | χ2 = 1.191 | 0.275 |
Mass + NME | 8 (20.0) | 38 (20.4) | χ2 = 14.719 | < 0.001 | 3 (17.6) | 6 (75.0) | χ2 = 3.525 | 0.060 |
Mass + Mass | 16 (40.0) | 50 (26.9) | χ2 = 8.847 | 0.003 | 6 (35.3) | 14 (17.5) | χ2 = 1.794 | 0.180 |
MIP_TRA | ||||||||
Linear | 10 (25.0) | 76 (40.9) | χ2 = 0.816 | 0.366 | 1 (5.9) | 26 (32.5) | χ2 = 1.575 | 0.209 |
Multiple punctate | 18 (45.0) | 4 (2.2) | χ2 = 34.67 | < 0.001 | 8 (47.0) | 4 (5.0) | χ2 = 1.166 | 0.280 |
Symmetric | 5 (12.5) | 27 (14.5) | χ2 = 0.687 | 0.407 | 3 (5.9) | 8 (10.0) | χ2 < 0.001 | 1.000 |
None | 7 (17.5) | 79 (42.5) | χ2 = 2.986 | 0.084 | 5 (29.4) | 42 (52.5) | χ2 < 0.001 | 1.000 |
Enhancement | ||||||||
Heterogeneous | 29 (72.5) | 146 (78.5) | χ2 = 0.039 | 0.843 | 16 (86.7) | 59 (73.8) | χ2 = 0.554 | 0.457 |
Homogeneous | 8 (20.0) | 29 (15.6) | χ2 = 0.075 | 0.784 | 1 (6.7) | 17 (21.3) | χ2 = 0.760 | 0.383 |
Rim enhancement | 3 (7.5) | 11 (5.9) | χ2 = 0.005 | 0.942 | 0 (6.7) | 4 (5.0) | χ2 < 0.001 | 1.000 |
Tumor size | 2.5 (1.1, 6.0) | 2.08 (0.50, 5.40) | 0.099 | 0.001 | 2.27 (1.3, 5.0) | 1.95 (0.80, 6.70) | χ2 = 0.751 | < 0.001 |
Time_Intensity_Curve | ||||||||
Type I | 3 (7.5) | 29 (15.6) | χ2 = 1.619 | 0.203 | 2 (11.8) | 20 (25.0) | χ2 < 0.001 | 1.000 |
Type II | 7 (17.5) | 61 (32.8) | χ2 = 0.078 | 0.780 | 8 (47.1) | 25 (31.3) | χ2 = 0.133 | 0.715 |
Type III | 30 (75.0) | 96 (51.6) | χ2 = 20.197 | < 0.001 | 7 (41.2) | 35 (43.8) | χ2 = 0.512 | 0.474 |
Margin | ||||||||
Clear | 3 (7.5) | 21 (11.29) | χ2 < 0.001 | 1.000 | 2 (11.8) | 10 (12.5) | χ2 = 0.025 | 0.875 |
Unclear | 8 (20.0) | 28 (15.05) | χ2 = 0.028 | 0.868 | 5 (29.4) | 16 (20.0) | χ2 = 0.088 | 0.767 |
Spiculated | 29 (72.5) | 137 (73.66) | χ2 = 0.089 | 0.766 | 10 (58.8) | 54 (67.5) | χ2 < 0.001 | 1.000 |
Shape | ||||||||
Irregular | 30 (75) | 111 (59.7) | χ2 = 0.294 | 0.588 | 14 (82.4) | 53 (66.3) | χ2 = 7.335 | 0.007 |
Roundish | 5 (12.5) | 59 (31.7) | χ2 = 0.545 | 0.460 | 3 (17.6) | 19 (23.8) | χ2 = 5.058 | 0.025 |
Multiple nodules | 5 (12.5) | 16 (8.6) | χ2 < 0.001 | 1.000 | 0 (0.0) | 8 (10.0) | χ2 = 0.301 | 0.583 |
MT | ||||||||
Tumor shape | ||||||||
High_Density_Nodule | 1 (2.5) | 9 (4.8) | χ2 < 0.001 | 1.000 | 0 (0.0) | 8 (10.0) | χ2 < 0.001 | 1.000 |
Regular mass | 21 (52.5) | 113 (60.8) | χ2 = 3.436 | 0.064 | 13 (76.5) | 46 (57.5) | χ2 = 9.529 | 0.002 |
Irregular mass | 3 (7.5) | 35 (18.8) | χ2 = 0.056 | 0.813 | 4 (23.5) | 13 (16.3) | χ2 = 11.054 | 0.001 |
Undetected | 15 (37.5) | 29 (15.6) | χ2 = 5.565 | 0.018 | 2 (11.8) | 13 (16.3) | χ2 = 235 | 0.628 |
Margin | ||||||||
Clear | 6 (15.0) | 24 (12.9) | χ2 = 1.108 | 0.292 | 3 (17.6) | 13 (16.3) | χ2 = 0.590 | 0.442 |
Unclear | 10 (25.0) | 83 (44.6) | χ2 < 0.001 | 0.993 | 7 (41.2) | 37 (46.3) | χ2 < 0.001 | 1.000 |
Spiculated | 9 (22.5) | 62 (33.3) | χ2 = 0.436 | 0.509 | 5 (29.4) | 24 (30.0) | χ2 < 0.001 | 1.000 |
Undetected | 15 (37.5) | 17 (9.14) | χ2 = 5.565 | 0.018 | 2 (11.8) | 6 (7.50) | χ2 = 0.235 | 0.628 |
US | ||||||||
Margin | ||||||||
Clear | 18 (45.0) | 55 (29.6) | χ2 = 0.604 | 0.437 | 3 (17.6) | 19 (23.8) | χ2 = 0.117 | 0.733 |
Unclear | 10 (25.0) | 72 (38.7) | χ2 = 1.084 | 0.298 | 9 (52.9) | 40 (50.0) | χ2 = 0.001 | 0.977 |
Spiculated | 9 (22.5) | 59 (31.7) | χ2 = 0.096 | 0.756 | 5 (29.4) | 21 (26.3) | χ2 = 0.009 | 0.926 |
Multifocality | ||||||||
Multifocality | 10 (25.0) | 29 (9.0) | χ2 = 0.383 | 0.536 | 4 (23.5) | 10 (12.5) | χ2 < 0.001 | 1.000 |
Univocality | 30 (75.0) | 157 (91.0) | 13 (76.5) | 70 (87.5) | ||||
ER | ||||||||
Positive | 31 (77.5) | 163 (87.6) | χ2 = 4.866 | 0.027 | 15 (88.2) | 71 (88.8) | χ2 = 0.301 | 0.583 |
Negative | 9 (22.5) | 23 (12.4) | 2 (11.8) | 9 (11.3) | ||||
PR | ||||||||
Positive | 30 (73.1) | 145 (78.0) | χ2 = 0.864 | 0.353 | 14 (82.4) | 67 (83.8) | χ2 = 0.295 | 0.587 |
Negative | 10 (26.9) | 41 (22.0) | 3 (17.6) | 13 (16.3) | ||||
Molecular subtypes | ||||||||
Luminal A | 9 (22.5) | 64 (34.4) | χ2 = 0.545 | 0.460 | 1 (6.7) | 31 (38.8) | χ2 = 0.643 | 0.423 |
LuminalB_Her2(-) | 16 (40.0) | 70 (37.6) | χ2 = 0.152 | 0.696 | 8 (47.1) | 33 (41.3) | χ2 = 2.363 | 0.124 |
LuminalB_Her2(+) | 5 (12.5) | 29 (15.6) | χ2 = 0.410 | 0.522 | 5 (29.4) | 9 (11.3) | χ2 < 0.001 | 1.000 |
HER2_enriched | 6 (15.0) | 6 (3.2) | χ2 = 9.549 | 0.002 | 2 (11.8) | 4 (5.0) | χ2 < 0.001 | 1.000 |
TNBC | 4 (10.0) | 17 (9.1) | χ2 = 0.008 | 0.928 | 0 (0.0) | 3 (3.8) | χ2 = 0.089 | 0.766 |
- Citation: Liu P, Zhao Y, Rong DD, Li KF, Wang YJ, Zhao J, Kang H. Diagnostic value of preoperative examination for evaluating margin status in breast cancer. World J Clin Cases 2023; 11(20): 4852-4864
- URL: https://www.wjgnet.com/2307-8960/full/v11/i20/4852.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v11.i20.4852