Copyright
©The Author(s) 2023.
World J Clin Cases. Jan 16, 2023; 11(2): 268-291
Published online Jan 16, 2023. doi: 10.12998/wjcc.v11.i2.268
Published online Jan 16, 2023. doi: 10.12998/wjcc.v11.i2.268
Table 2 Main factors for post-transplant immune reconstitution
Factors | Effect | Ref. |
Recipient age | Several studies show that immune reconstitution, especially the reconstitution of CD4+ T cells, is inversely related to age. However, some studies report that age has no effect on the reconstitution of any subgroup of lymphocytes | [63,90,91] |
Graft source | Immune reconstitution occurs faster after PBSCT than after BMT. This may be because PBSCT grafts are rich in mature lymphocytes. Delayed immune reconstitution after UCBT is related to low lymphocyte count and immature immune cells in umbilical cord blood | [61,92-95] |
HLA matching between donor and recipient | HLA mismatch causes delayed reconstitution of neutrophils and T cells | |
Intensity of preconditioning | Several studies show that compared with MA-SCT, RICSCT reduces thymus damage and promotes immune reconstitution. However, some studies show no significant difference in recipient immune reconstitution between these two transplantation methods | [60,96-98] |
GVHD | GVHD damages thymus structure and function and interferes with T cell differentiation at all stages, thereby affecting T cell reconstitution. GVHD also affects the recovery of B cell number and function | [84,99] |
GVHD prevention | Donor TCD reduces the risk of GVHD; however, the lack of T cells increases the risk of infection and delayed immune reconstitution | [100] |
The use of ATG or alemtuzumab has a negative effect on the reconstitution of T cells and B cells | [101-103] |
- Citation: Chen YF, Li J, Xu LL, Găman MA, Zou ZY. Allogeneic stem cell transplantation in the treatment of acute myeloid leukemia: An overview of obstacles and opportunities. World J Clin Cases 2023; 11(2): 268-291
- URL: https://www.wjgnet.com/2307-8960/full/v11/i2/268.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v11.i2.268