Network pharmacology and molecular docking-based analyses to predict the potential mechanism of Huangqin decoction in treating colorectal cancer

Figure 3 The core target screening process. A: All potential targets of Huangqin decoction in the treatment of colorectal cancer (purple nodes); B: Core targets screened based on CytoNCA (yellow nodes); C: The top 28 targets screened by betweenness, closeness, degree, eigenvector, local average connectivity and network values of topology parameters. JUN: Jun proto-oncogene, AP-1 transcription factor subunit; STAT3: Signal transducer and activator of transcription 3; TP53: Tumor protein p53; VEGFA: Vascular endothelial growth factor; AKT1: AKT serine/threonine kinase 1 (AKT1); MAPK: Mitogen-activated protein kinase; EGFR: Epidermal growth factor receptor.