Copyright
©The Author(s) 2023.
World J Clin Cases. Jul 6, 2023; 11(19): 4458-4476
Published online Jul 6, 2023. doi: 10.12998/wjcc.v11.i19.4458
Published online Jul 6, 2023. doi: 10.12998/wjcc.v11.i19.4458
Table 2 Various therapies prescribed for the treatment of irritable bowel syndrome along with their possible mode of action
Therapy | Description | Proposed mechanism(s) of action |
Prebiotics | Ingested compounds targeted to stimulate gut microbiota | Mechanism of action undefined, but may include: Anti-inflammatory effects; inhibition of pathogen adherence; and growth of intestinal mucosal layer |
Probiotics | Ingested microorganisms (e.g., bacteria) | Mechanism of action undefined, but may include: Inhibition of pathogenic microorganism colonization; support intestinal barrier integrity and function; production of beneficial micronutrients; and activation and augmentation of the enteric nervous system |
Rifaximin | Nonabsorbable, bile-soluble antibiotic indicated for the treatment of adults with IBS-D | Antibacterial against Gram-positive and Gram-negative bacteria: Modulation of gut-immune signalling; inhibition of bacterial translocation; SIBO eradication (in some patients); causing decreases in GI methane concentrations in combination; and with the antibiotic neomycin (in patients with IBS-C) |
SBI | Prescription medical food for patients with IBS-D | Modulation of gut microbiota: Causing decreases in GI permeability |
SYN-010 | Derivative of the HMG-CoA reductase inhibitor lovastatin lactone; currently in development for the treatment of patients with IBS-C | Inhibition of methane production by Methanobrevibacter smithii |
Dietary modification | Variable; one example is the low FODMAP diet | Causing decreases in GI gas production |
Causing decreases in intra-luminal fluid production |
- Citation: Singh SV, Ganguly R, Jaiswal K, Yadav AK, Kumar R, Pandey AK. Molecular signalling during cross talk between gut brain axis regulation and progression of irritable bowel syndrome: A comprehensive review. World J Clin Cases 2023; 11(19): 4458-4476
- URL: https://www.wjgnet.com/2307-8960/full/v11/i19/4458.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v11.i19.4458