Synchronous endometrial and ovarian cancer: A case report

Figure 3 Crosstalk of PI3K/AKT and WNT pathways in synchronous endometrial and ovarian. Both pathways converge at glycogen synthase kinase-3 beta (GSK3β): In PI3K/AKT pathway, activation of PI3K is required for AKT activation and downstream signaling. PTEN acts as deactivator of PI3K pathway. AKT also phosphorylates and inactivates GSK3β. Meanwhile in WNT signaling GSK3β/Axin complex is required for β-catenin phosphorylation and degradation. The numbers indicate TCGA published mutation data form uterine (right side data) and ovarian (left side data) cancers. Figure generated using PathwayMapper tool. GSK3β: Glycogen synthase kinase-3 beta.