Hypoperfusion context as a predictor of 28-d all-cause mortality in septic shock patients: A comparative observational study

Table 5 Cutoff values of perfusion markers at specified intervals

Marker	Cutoff value	Sensitivity	Specificity	PPV	NPV	Accuracy	P value
Lactate at 0 h	> 4.9	55.2%	63.2%	29.1%	83.8%	61.5%	0.074
Lactate at 3 h	> 4.2	65.5%	77.4%	44.2%	89.1%	74.8%	< 0.001a
Lactate at 6 h	> 4.1	74.1%	84.9%	55.6%	92.8%	82.7%	< 0.001a
Lactate clearance at 3 h	≤ -20.6 (≥ 20.6% from baseline)	44.8%	93.4%	65.0%	86.1%	83.0%	< 0.001a
Lactate clearance at 6 h	≤ -46.4 (≥ 46.4% from baseline)	55.6%	94.3%	71.4%	89.3%	86.5%	< 0.001a
CRT at 0 h	> 4	55.2%	67.9%	32.0%	84.7%	65.2%	0.022a
CRT at 3 h	> 4	69.0%	70.8%	39.2%	89.3%	70.4%	< 0.001a
CRT at 6 h	> 8	51.9%	94.3%	70.0%	88.5%	85.7%	< 0.001a
ScvO2 at 0 h	> 71.7	55.2%	71.7%	34.8%	85.4%	68.2%	0.007a
ScvO2 at 3 h	> 61.7	69.0%	53.8%	29.0%	86.4%	57.0%	0.03a
ScvO2 at 6 h	≤ 58.9	55.6%	65.1%	28.9%	85.2%	63.2%	0.05
P(cv-a)CO2 at 0 h	> 7.6	44.8%	81.1%	39.4%	84.3%	73.3%	0.004a
P(cv-a)CO2 at 3 h	> 5.9	72.4%	73.6%	42.9%	90.7%	73.3%	< 0.001a
P(cv-a)CO2 at 6 h	> 6.4	63.0%	83.0%	48.6%	89.8%	79.0%	< 0.001a

^aDenotes statistical significance.

CRT: Capillary refill time; NPV: Negative predictive value; P(cv-a)CO₂: Central venous-arterial pCO₂ gradient; PPV: Positive predictive value; ScvO₂: Central venous oxygen saturation.