Hypoperfusion context as a predictor of 28-d all-cause mortality in septic shock patients: A comparative observational study

doi:10.12998/wjcc.v11.i16.3765

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Clin Cases. Jun 6, 2023; 11(16): 3765-3779
Published online Jun 6, 2023. doi: 10.12998/wjcc.v11.i16.3765

Table 3 Comparison of survivors and non-survivors

Variable	Non-Survivors			Survivors			P value
Variable	mean ± SD	Min-Max	Median (Q1-Q3)	mean ± SD	Min-max	Median (Q1-Q3)	P value
Age	62.41 ± 14.61	28-82	66 (55.5-74.0)	61.82 ± 14.55	20-92	64 (53.75-71.25)	0.653
APACHE II	23.93 ± 4.91	14-32	24 (20.5-28.0)	21.08 ± 5.64	8-33	21 (17.00-25.25)	0.012^a
SOFA score	10.38 ± 4.71	2-17	11 (6-15)	8.81 ± 3.73	2-18	8 (6-11)	0.094
HB	12.2 ± 11.0	7.2-16.7	10 (8.8-12.0)	10.6 ± 2.0	7.1-16.9	10.3 (9.1-12.0)	0.493
TLC	10.0 ± 6.9	0.2-24.3	8.5 (5.4-13.8)	13.1 ± 8.6	0.1-46.5	11.9 (6.8-16.7)	0.101
PLT	1.99 ± 0.89	0.25-4.08	1.83 (1.58-2.01)	2.18 ± 0.95	0.10-5.26	2.10 (1.65-2.78)	0.188
SBIL	1.02 ± 0.84	0.28-4.70	0.78 (0.57-1.27)	2.00 ± 2.90	0.16-18.57	0.8 (0.5-2.0)	0.489
SALB	2.4 ± 0.4	1.6-3.1	2.3 (2.1-2.7)	3.1 ± 0.6	1.5-4.4	3.1 (2.7-3.5)	< 0.001^a
INR	1.28 ± 0.29	0.97-2.14	1.18 (1.09-1.31)	1.36 ± 0.36	0.95-3.83	1.30 (1.12-1.48)	0.099
CREAT	2.08 ± 0.95	0.50-4.90	1.80 (1.50-2.40)	1.36 ± 1.23	0.20-10.50	1.10 (0.60-1.80)	< 0.001^a
Urea	61.24 ± 44.91	9.90-229.00	45.60 (30.50-86.70)	49.99 ± 31.30	3.30-168.90	41.83 (30.10-61.60)	0.280
HR	107.00 ± 15.22	70-128	112 (98-118)	104.34 ± 15.58	64-156	106.50 (94.00-116.00)	0.228
SBP	94.66 ± 22.81	60-138	90 (74-116)	102.71 ± 21.45	50-166	102 (90-118)	0.065
DBP	52.41 ± 14.21	26-87	50 (41-60)	58.77 ± 15.41	24-97	60.00 (46.00-69.25)	0.060
MAP	66.24 ± 16.61	31-101	67.0 (53.0-76.5)	73.42 ± 15.74	33-106	71 (64-85)	0.057
Lactate at 0 h	5.20 ± 1.72	2.10-9.40	5.20 (4.0-5.70)	4.74 ± 1.69	2.30-9.80	4.40 (3.40-5.90)	0.151
Lactate at 3 h	5.54 ± 2.14	2.40-10.70	5.20 (3.80-6.70)	3.71 ± 1.80	1.30-12.40	3.40 (2.50-4.20)	< 0.001^a
Lactate at 6 h	6.61 ± 3.35	2.10-14.60	6.30 (3.90-8.60)	3.21 ± 2.70	0.60-16.70	2.45 (1.90-3.30)	< 0.001^a
CRT at 0 h	5.07 ± 2.46	2-12	5 (3-7)	4.07 ± 2.18	1-9	3 (2-6)	0.040^a
CRT at 3 h	6.38 ± 2.95	2-13	6 (4-8)	3.82 ± 2.14	1-10	3 (2-5)	< 0.001^a
CRT at 6 h	7.10 ± 4.10	2-13	9 (3-11)	3.63 ± 2.64	1-13	2.5 (2.0-5.0)	< 0.001^a
ScvO₂ at 0 h	68.30 ± 7.80	43.20-73.90	71.9 (70.2-72.8)	66.20 ± 8.50	42.80-74.20	70.80 (58.90-71.90)	0.033^a
ScvO₂ at 3 h	61.90 ± 7.10	45.80-73.50	62.8 (58.9-66.2)	61.00 ± 6.50	36.80-73.70	61.70 (57.80-64.90)	0.304
ScvO₂ at 6 h	58.10 ± 11.80	36.70-89.20	58.9 (49.7-66.2)	60.2 ± 7.60	37.90-71.0	61.90 (56.10-65.90)	0.299
P(cv-a)CO₂ at 0 h	6.50 ± 1.90	2.80-9.40	7.3 (4.9-7.9)	5.70 ± 1.90	2.80-9.80	5.50 (4.20-7.40)	0.036^a
P(cv-a)CO₂ at 3 h	7.00 ± 2.10	3.40-12.30	6.5 (5.6-8.6)	5.20 ± 1.60	2.7-11.0	4.8 (4.0-6.2)	< 0.001^a
P(cv-a)CO₂ at 6 h	7.10 ± 2.50	2.60-10.80	7.4 (4.9-9.2)	5.40 ± 4.50	2.60-8.70	4.70 (3.60-5.80)	< 0.001^a
Lactate clearance at 3 h	(-10.20 ± 35.10)	(-88.10-40.40)	(-8.6) (-37.1-24.7)	18.80 ± 34.20	(-183.30-58.20)	26.80 (7.30-37.20)	< 0.001^a
Lactate clearance at 6 h	(-28.70 ± 72.80)	(-187.0-100.0)	(-46.4) (-61.5-29.9)	29.20 ± 64.40	(-433.80-81.30)	44.90 (23.40-58.70)	< 0.001^a

^aDenotes statistical significance.

APACHE: Acute Physiology and Chronic Health Evaluation; CREAT: Creatinine; CRT: Capillary refill time; DBP: Diastolic blood pressure; HB: Hemoglobin; HR: Heart rate; INR: International normalized ratio; MAP: Mean arterial pressure; P(cv-a)CO₂: Central venous-arterial pCO₂ gradient; PLT: Platelet; Q1: First quartile; Q3: Third quartile; SALB: Serum albumin; SBIL: Serum bilirubin; SBP: Systolic blood pressure; ScvO₂: Central venous oxygen saturation; SD: Standard deviation; SOFA: Sequential Organ Failure Assessment; TLC: Total leukocyte count.

Citation: Kataria S, Singh O, Juneja D, Goel A, Bhide M, Yadav D. Hypoperfusion context as a predictor of 28-d all-cause mortality in septic shock patients: A comparative observational study. World J Clin Cases 2023; 11(16): 3765-3779
URL: https://www.wjgnet.com/2307-8960/full/v11/i16/3765.htm
DOI: https://dx.doi.org/10.12998/wjcc.v11.i16.3765