Helicobacter pylori plays a key role in gastric adenocarcinoma induced by spasmolytic polypeptide-expressing metaplasia

doi:10.12998/wjcc.v11.i16.3714

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Jun 6, 2023; 11(16): 3714-3724
Published online Jun 6, 2023. doi: 10.12998/wjcc.v11.i16.3714

Table 2 The influence of the absence of additional signals and epidermal growth factor

Genotype	SPEM	IM	Neoplasia
AR-null mouse	Yes	Yes	Yes
TGF-α-null mouse	No	No	No
IL33 KO mouse + L635	No	No	No
ST2 KO mouse + L635	No	No	No
IL13 KO mouse + L635	No	No	No
IFN-γ overexpression mouse	Yes	No	No

SPEM: Spasmolytic polypeptide-expressing metaplasia; AR: Amphiregulin; TGF: Transforming growth factor; IL: Interleukin; IFN: Interferon; IM: Intestinal metaplasia; KO: Knockout.

Citation: Li ML, Hong XX, Zhang WJ, Liang YZ, Cai TT, Xu YF, Pan HF, Kang JY, Guo SJ, Li HW. Helicobacter pylori plays a key role in gastric adenocarcinoma induced by spasmolytic polypeptide-expressing metaplasia. World J Clin Cases 2023; 11(16): 3714-3724
URL: https://www.wjgnet.com/2307-8960/full/v11/i16/3714.htm
DOI: https://dx.doi.org/10.12998/wjcc.v11.i16.3714