Impact of heart failure on outcomes in patients with sepsis: A systematic review and meta-analysis

Table 1 Characteristics of the studies and quality assessment

Ref.	Year	Setting	Study design	Sepsis severity	Diagnosis of HF	Outcomes	ORs	NOS score (S C O)
Grozdanovski et al[19]	2012	Single-centre, ICU, Republic of Macedonia	Prospective	Severe sepsis/septic shock	Confirmed by medical record	Hospital mortality	Adjusted	4 1 2
cui et al[9]	2014	Single-centre, ICU, China	Retros-pective	Severe sepsis/septic shock	Confirmed by medical record	Hospital mortality	Unadjusted	3 1 2
Lemay et al[4]	2014	Multicenter, database about medicare hospital, United States	Prospective	Severe sepsis	Confirmed by database of the Department of Veterans’ Affairs Health Care systems	Long-term mortality	Adjusted	4 2 3
Mourad et al[20]	2014	Single-centre, ICU, France	Prospective	Septic shock	Selection with diastolic dysfunction by echocardiography and medical record	Hospital mortality	Adjusted	4 2 2
Vallabhajosyula et al[12]	2017	Single-centre, ICU, United States	Retros-pective	Severe sepsis/septic shock	Selection with ventricular dysfunction by echocardiography and medical record	1-year mortality	Adjusted	4 2 3
Abu-Kaf et al[21]	2018	Single-centre, ICU databases, Israel	Retros-pective	Severe sepsis	Confirmed by medical record in ISR-SEPSIS	2-year mortality	Unadjusted	4 2 2
Arnautovic et al[6]	2018	Multicenter, ICU, United States	Retros-pective	Septic shock	Confirmed by medical record	Hospital mortality	Adjusted	4 2 2
Schuler et al[11]	2018	Multicenter, medicare hospital, United States	Retros-pective	Sepsis	Assessment of cardiac failure with SOFA score	long-term mortality	Adjusted	4 2 3
Kim et al[22]	2020	Single-centre, medicare hospital, United States	Retros-pective	Septic shock	Selection with ventricular dysfunction by echocardiography and medical record	28- day mortality	Adjusted	4 2 2
Hiraiwa et al[23]	2021	Single-centre, ICU database, Japan	Retrospective	Septic shock	Selection with ventricular dysfunction by echocardiography and medical record in MIMIC-III	Hospital mortality	Adjusted	4 2 3

HF: Heart failure; ORs: Odds ratios; NOS: Newcastle-Ottawa scale; ICU: Intensive care unit; ISR-SEPSIS: Israeli Sepsis Group database; SOFA: Sequential organ failure assessment; MIMIC-III: Medical Information Mart for Intensive Care III database.