Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: A case report and review of literature

Figure 4 Scheme of tyrosine kinase inhibitor activity. In order to activate signal transduction cascades, tyrosine kinase receptors must be phosphorylated by a tyrosine kinase in addition to binding with their specific ligands. Tyrosine kinase inhibitors block the activity of tyrosine kinases via different mechanisms. TKI: Tyrosine kinase inhibitor; P: Phosphate; PI3L/Akt: Phosphatidylinositol-3-kinase/Akt; MAPK: Mitogen-activated protein kinase; JAK/STAT: Janus kinase/signal transducer and activator of transcription.