Classification of osteogenesis imperfecta: Importance for prophylaxis and genetic counseling

Figure 1 Clinical osteogenesis imperfecta classification (severity). OI type I – mild form with blue sclerae, hearing loss; OI type IV – mild to moderate form with normal sclerae; OI type III - progressively deforming; OI type II – extremely severe form, lethal perinatal outcome with radiographically broad, crumpled femora and beaded ribs (Created with BioRender.com). OI: Osteogenesis imperfecta.