Surgical management of pituitary adenoma during pregnancy

Table 2 Treatment and follow-up outcomes of pregnant patients who underwent surgery for pituitary adenoma

Ref.	Case	Treatment				Pathology	Follow up
		Medical therapy		Operation	Delivery		M	I
		Pre	Post
Peking Union Medical College Hospital	1	Bromocriptine	No	12th W TSS	40th W CS	NF PA	ER	H
	2	No	No	32nd W TSS	Full term CS	NF PA	ER	H
	3	No	No	22nd W TSS	38th W CS	NF PA	ER	H
	4	Sandostatin	No	26th W TSS	38th W CS	TSH PA	ER	H
	5	Bromocriptine	No	35th W TSS	35th W CS	PRL PA	ER	H
	6	Prednisone, thyroxine	Prednisone, thyroxine	30th W TSS	39th W CS	NF PA	ER	H
Jallad et al[16]	7	No	No	3rd Mon TSS	38thW CS	GH PA	ER	H
	8	No	No	4th Mon TSS	16th W A	GH PA	EC	A
	9	Cabergoline	No	4th Mon TSS	39th W CS	GH PA	ER	H
Chaiamnuay et al[17]	10	Propylthiouracil, bromocriptine	No	27th W TSS	39th W CS	TSH PA	ER	H
Guven et al[18]	11	No	Octreotide	34th W TSS	34th W CS	GH PA	EC	H
Zhong et al[38]	12	No	Cortisone, thyroxine	22nd W TSS	40th W VD	NF PA	ER	H
Jemel et al[19]	13	Cabergoline, hydrocortisone	No	22nd W TSS	37th W VD	NF PA	ER	H
	14	Corticosteroids	No	24th W TSS	38th W VD	NF PA	ER	H
Xia et al[20]	15	No	No	24th W TSS	38th W CS	PRL PA	ER	H
Yamaguchi et al[21]	16	No	Methyl prednisolone	36th W TSS	37th W CS	PRL PA, Optic neuritis	ER	H
Tandon et al[22]	17	Bromocriptine	Desmopressin	36th W TSS	37th W CS	PRL PA	ER	H
Parihar et al[36]	18	No	No	20th W TSS	Full term VD	PRL PA	ER	H
Gondim et al[23]	19	Bromocriptine	Thyroxine, hydrocortisone	32nd W TSS	39th W VD	PRL PA	EC	H
Witek et al[24]	20	Bromocriptine	Hydrocortisone	20th W TSS	38th W CS	PRL PA	ER	H
Kita et al[25]	21	No	DDAVP	27th W TSS	40th W VD	NF PA	ER	H
Nossek et al[26]	22	No	No	33rd W TSS	35th W CS	PA	ER	LAS
	23	No	No	31st W TSS	40th W VD	PA	ER	H
Iuliano and Laws[27]	24	Bromocriptine, dexamethasone	No	30th W TSS	39th W CS	NF PA	ER	H
	25	Bromocriptine, dexamethasone	Levothyroxine, hydrocortisone	33rd W TSS	39th W CS	NF PA	ER	H
Hayes et al[28]	26	Corticosteroids	No	18th W TSS	Full term VD	PRL PA	ER	H
Boronat et al[52]	27	Alpha-metildopa	Metyrapone	16th W TSS	34th W VD	ACTH PA	R	H
Abbassy et al[37]	28	No	Hydrocortisone, desmopressin	18th W TSS	39th W VD	ACTH PA	ER	H
Coyne et al[53]	29	No	Hydrocortisone, desmopressin	14th W TSS	38th W VD	ACTH PA	ER	H
Pinette et al[54]	30	No	Atenolol	16th W TSS	-	ACTH PA	ER	D
Ross et al[55]	31	No	Dexamethasone	18th W TSS	37th W CS	ACTH PA	ER	H
Mellor et al[51]	32	No	Hydrocortisone	Mid-trimester TSS	34th W CS	ACTH PA	ER	H
Karaca et al[15]	33	No	No	11th W TSS	39th W CS	GH PA	ER	H
Jolly et al[56]	34	No	Hydrocortisone, metformin, labetalol, nifedipine	23rd W TSS	38th W CS	ACTH PA	ER	D
Galvão et al[29]	35	No	No	2nd trimester TSS	-	PRL PA	ER	H
Abid et al[30]	36	Bromocriptine	Lisuride hydrogen	27th W TSS	39th W VD	PRL PA	ER	H
Barraud et al[31]	37	Bromocriptine	No	4th Mon TSS	-	PRL PA	ER	H
Freeman et al[32]	38	DDAVP	Hydrocortisone, thyroxine, DDAVP	32nd W TSS	39th W VD	PRL PA	ER	H
Lunardi et al[33]	39	No	No	6th Mon TSS	Full term VD	GH PA	EC	H
Oguz et al[34]	40	No	Levothyroxine	23rd W TSS	37th W CS	PRL PA	ER	H
O’Neal[35]	41	Hydrocortisone, bromocriptine	No	29th W TSS	37th W VD	PA	ER	H

A: Abortion; ACTH: Adrenocorticotropic hormone; CS: Cesarean section; D: Death; DDAVP: 1-Desamino-8-D-arginine vasopressin; EC: Endocrine control; ER: Endocrine remission; GH: Growth hormone; H: Healthy; I: Infant; LAS: Low Apgar score; M: Maternal; NA: Not available; NF: Nonfunctional; PA: Pituitary adenoma; Post: Postoperatively; Pre: Preoperatively; PRL: Prolactin; R: Recurrence; TSH: Thyroid stimulating hormone; TSS: Transsphenoidal surgery; VD: Vaginal delivery.