Controversies in the management of acute pancreatitis: An update

Table 3 Randomized controlled trials comparing aggressive vs restricted fluid resuscitation in the inflammatory phase of acute pancreatitis

Ref.	No. of patients	Disease severity	Aggressive resuscitation	Non-aggressive resuscitation
Mao et al[22], 2009	Aggressive: 36	SAP	Mortality: 94.4%	Mortality: 10.0%
	Non-aggressive: 40		Mechanical ventilation: 30.6%	Mechanical ventilation: 65.0%
Mao et al[23], 2010	Aggressive: 56	SAP	Mortality: 33.9%	Mortality: 15.3%
	Non-aggressive: 59		Sepsis: 78.6%	Sepsis: 57.6%
Wu et al[15], 2011	Aggressive: 19		Reduction in SIRS: 58%	Reduction in SIRS: 42%
	Non-aggressive: 21
Buxbaum et al[24], 2017	Aggressive: 27	Mild AP	Clinical improvement: 70%	Clinical improvement: 42%
	Non-aggressive: 33		SIRS: 7.4%	SIRS: 21.1%
Cuellar-Monterrubeo et al[25], 2020	Aggressive: 43	Mild, moderately severe and severe AP	SIRS at day 7: 13.3%	SIRS at day 7: 13.9%
	Non-aggressive: 45
Li et al[26], 2020	Total number (n = 912)	Hemoconcentration hematocrit > 44% vs < 44%	In hematocrit > 44%: increased NPPV	In hematocrit < 44%: reduced risk of NPPV

AP: Acute pancreatitis; NPPV: Non-invasive positive pressure ventilation; SAP: Severe acute pancreatitis; SIRS: Systemic inflammatory response syndrome.