Controversies in the management of acute pancreatitis: An update

Table 1 Randomized controlled trials comparing resuscitation with Ringer’s lactate vs normal saline in the initial acute phase of acute pancreatitis

Ref.	RL	NS	SIRS			CRP
Wu et al[15], 2011	19	21	RL	84% at 24 h	P = 0.035	RL	Mean CRP 51 mg/L	P = 0.018
			NS	0% reduction at 24 h		NS	Mean CRP 104 mg/L
de Madaria et al[13], 2018	19	21	RL	Median no of SIRS criteria at 48 h: 01 (0-1)	P = 0.060	RL	Mean CRP at 48 h: 28 mg/L	P = 0.037
			NS	Median no of SIRS criteria at 48 h: 01 (1-2)		NS	Mean CRP at 48 h: 166 mg/L
Choosakul et al[14], 2018	23	24	RL	Reduction in SIRS at 48 h: 26.1%	P = 0.02	No difference in CRP
			NS	Reduction in SIRS at 48 h: 26.1% 4.2%
Karki et al[16], 2022	26	25	RL	SIRS at 24 h: 15.4%	P = 0.025	Median CRP at 72 h: 14.2 mg/L		P < 0.001
			NS	SIRS at 24 h: 44.0%		Median CRP at 72 h: 22.2 mg/L

CRP: C-reactive protein; NS: Normal saline; RL: Ringer’s lactate; SIRS: Systemic inflammatory response syndrome.