Successful treatment of lichen amyloidosis coexisting with atopic dermatitis by dupilumab: Four case reports

Figure 3 Case 3. A and B: Dense distribution of hard brown papules was observed on the chest plus papules on the thighs, with a "goose bump" appearance presenting at baseline, suggestive of atopic dermatitis; C and D: After 16 wk of treatment, the rash on the lower limbs markedly improved, and the papules were reduced and became flat; E: Histopathology revealed hyperkeratosis with incomplete keratosis and irregular acanthosis. Further, a pink amorphous material can be seen in the dermal papilla (hematoxylin & eosin staining, × 100); F: Crystal violet staining was positive for amyloid (crystal violet staining, × 400). The arrow indicates amyloid deposits.