Successful treatment of lichen amyloidosis coexisting with atopic dermatitis by dupilumab: Four case reports

Figure 2 Case 2. A and B: Dense distribution of hard brown papules was observed on both lower limbs, with scales on the surface and dry and rough skin at baseline. Moreover, post-inflammatory hypopigmentation was evident on the anterior aspects of the calves; C and D: After 16 wk of treatment, the rash on both lower limbs was markedly reduced, the papules became flat, the scales were reduced, and the skin became smooth. Furthermore, the rippled appearance of the lesions of the posterior thighs has considerably diminished after the treatment, suggesting a decreased burden of amyloid deposits; E: Histopathological examination revealed epidermal hyperkeratosis, irregular hyperplasia of the spinous layer, increased basal pigmented cells, and red mass material deposition in the dermal papilla (hematoxylin & eosin staining, × 100); F: Crystal violet staining was positive for amyloid bodies (crystal violet staining, × 400). The arrow indicates amyloid deposits.