Hepatobiliary system and intestinal injury in new coronavirus infection (COVID-19): A retrospective study

doi:10.12998/wjcc.v11.i10.2226

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Clin Cases. Apr 6, 2023; 11(10): 2226-2236
Published online Apr 6, 2023. doi: 10.12998/wjcc.v11.i10.2226

Table 4 Intestinal microbiota indications in coronavirus disease 19 patients compared with the control group Me (UQ; LQ)

Symptom	Patients with COVID-19 (n = 80)	Control group (n = 17)	P value
Eubacterium/Cl. Coccoides, amt. × 10⁵/г	6849 (3380-7987)	8211 (2996-10987)	0.17
Herpes, amt. × 10⁵/г	0.00 (0.00-1808.25)	3610 (1914-5316)	0.001
Propionibacterium/Cl. Subterminale, amt. × 10⁵/г	2706 (1614-3476)	1992 (704-2118)	0.0016
Bifidobacteria, amt. × 10⁵/г	3768 (2000-4678)	4614 (1653-6123)	0.13
Fungus, amt. × 10⁵/г	1200 (423-1851)	540 (384-774)	0.0406
Lactobacillus, amt. × 10⁵/г	7488 (4221-8790)	4309 (2521-5198)	0.0016
The ratio of anaerobic to aerobic flora	1.801 (0.718-3.01)	1.983 (0.637-3.09)	0.39
The ratio of beneficial flora to opportunistic	1.009 (0.359-2.110)	0.992 (0.300-1.990)	0.86
Beneficial flora, amt. × 10⁵/г	20953 (5508-36018)	19126 (3930-35764)	0.18
Sum, amt. × 10⁵/г	44651 (8152-97098)	42566 (6297-89016)	0.33
Large intestine (anaerobes), amt. × 10⁵/г	26171 (7088-44099)	24964 (4423-43871)	0.44
Small intestine (aerobes), amt. × 10⁵/г	15944 (4620-19087)	13570 (3692-20114)	0.06
Opportunistic flora, amt. × 10⁵/г	21927 (5493-25900)	19849 (3690-23983)	0.11
Cytomegalovirus, amt. × 10⁵/г	0.00 (0.00-40.00)	0.00 (0.00-0.00)	0.12
Endotoxin (sum), amt. × 10⁵/г	2.44 (1.21-6.11)	0.689 (0.490-1.11)	0.0000779

Propionibacterium /Cl. Subterminale, content of fungi, lactobacill ratios significantly changed among mild and moderate COVID-19 patients compared with the control group. It is extremely important to note a significant (more than 3 times) and statistically significant (P = 0.0000779) increase in endotoxin content. At the same time, the content of endotoxin in feces in patients with mild to moderate severity of new coronavirus infection did not differ significantly. COVID-19: Coronavirus disease 19.

Citation: Kozlov KV, Zhdanov KV, Ratnikova AK, Ratnikov VA, Tishkov AV, Grinevich V, Kravchuk YA, Miklush PI, Nikiforova PO, Gordienko VV, Popov AF, Andryukov BG. Hepatobiliary system and intestinal injury in new coronavirus infection (COVID-19): A retrospective study. World J Clin Cases 2023; 11(10): 2226-2236
URL: https://www.wjgnet.com/2307-8960/full/v11/i10/2226.htm
DOI: https://dx.doi.org/10.12998/wjcc.v11.i10.2226