Hepatobiliary system and intestinal injury in new coronavirus infection (COVID-19): A retrospective study

Table 3 Factors characterizing intestinal permeability in patients with coronavirus disease 19 compared with the control group, depending on the severity of the disease Me (UQ; LQ)

Indication	COVID-19 patients (n = 80)	Control Group (n = 17)	P value	COVID-19 patients, mild severity (n = 19)	COVID-19 patients, moderate severity (n = 61)	P value
Fecal calprotectin (mg/g)	87.5 (53.525-227.75)	109.65 (23.275-213.75)	0.97	53.1 (21.0-153.0)	105.0 (58.2-236.0)	0.018
Zonulin, feces (ng/mL)	141 (110-180)	64.4 (32.1-74.8)	0.003	134.9 (78.8-167.5)	143 (119-155.9)	0.74
Zonulin, blood (ng/mL)	67.9 (20.3-77.8)	85.7 (23.0-98.1)	0.039	67.9 (20.3-76.1)	71.1 (20.0-81.7)	0.55

The content of fecal calprotectin in the control group and in patients with COVID-19 did not differ statistically significantly. At the same time, the concentration of zonulin in feces in patients with COVID-19 was statistically significantly higher than in the control group (P = 0.003). At the same time, the content of zonulin in the blood in patients with COVID-19 was lower than in the control group (P = 0.046). COVID-19: Coronavirus disease 19.