Endplate role in the degenerative disc disease: A brief review

Table 2 Summary of the main events in endplate degeneration process

Main inflammatory mediators in the endplate degenerative process	Features of endplate degeneration	Main molecular changes
Interleukin-1β	Alterations in bone composition and morphology	Degradation of aggrecan and collagen II
Tumour necrosis factor (TNF)-α	Decreasing of endplate thickens	Rise in matrix metalloproteinase actvity
Macrophage inhibition factor	Loss of blood vessels	Increased cell death
Interleukin-6	Loss of cartilage
	Increased endplate porosity